急性心肌梗塞患者治疗前后血浆心钠素水平的比较  

Comparison of Plasma Level of Artrial Natriuretic Factor in Patients with Acute Myocardial Infarction before and after Treatment

作　　者：肖玉艳[1] 贾文军[1] 刘之武[1] 朱军[2] 

机构地区：[1]天津市公安医院,天津300050 [2]天津津城放免中心

出　　处：《标记免疫分析与临床》1999年第3期152-154,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：测定了４９ 例急性心肌梗塞（ Ａ Ｍ Ｉ） 患者治疗前、后血浆心钠素（ Ａ Ｎ Ｐ） 的水平。结果表明， 治疗前 Ａ Ｎ Ｐ 测定值为４０５ ．５４ ±１２７ ．４１ ｐｇ／ｍ Ｌ， 治疗后为３４２ ．３４ ±１３０ ．５１ｐｇ／ ｍ Ｌ。而对照组为２７５ ．１１ ±１２０ ．６３ｐｇ／ ｍ Ｌ。两组相比，前者差别非常显著（ Ｐ＜ ０ ．０１） ，后者差别亦显著（ Ｐ＜０ ．０５） 。 Ａ Ｍ Ｉ组治疗后 Ａ Ｎ Ｐ 水平明显下降， 与治疗前比较差别显著（ Ｐ＜ ０ ．０５） 。本文对此做了讨论， 提出 Ａ Ｍ Ｉ 时 Ａ Ｎ Ｐ 的增高可能与心室顺应性改变和心功能不全以及心肌受损有关， 是保护内环境稳定的一种代偿机制。In order to study the relation between artrial natriuretic polypeptide (ANP) and acute myocardial infarction (AMI), plasma level of ANP was determined in 49 patients with AMI within 24 hours of onset and two weeks after treatment by radioimmunoassay(RIA). The results showed the plasma concentration of ANP in 49 patients with AMI within 24 hours of onset was 405.54±127.41pg/mL and was 342.34±130.51pg/mL, two weeks after treatment, which were both higher than that of the normal group (275.11±120.63pg/mL) respectively ( P <0.01 and P <0.05).The author considers that in patients suffered from AMI, the high concentration of ANP in plasma might be a compensatory mechanism and could improve the prognosis of patients.

关 键 词：急性 心肌梗塞 心钠素 ANP 

分 类 号：R542.220.2[医药卫生—心血管疾病]