雌性山羊去卵巢后不同时间骨生物力学参数变化  

Changes of Biomechanical Properties in Goats at Different Times after Ovariectomy

作　　者：何成明[1,2] 陈槐卿[1] 李良[1] 陈孟诗[3] 陈云爽[1] 吴文超[1] 

机构地区：[1]华西医科大学生物医学工程研究室,成都610041 [2]四川畜牧兽医学院生物技术系,重庆荣昌402460 [3]四川大学生物力学研究所,成都610065

出　　处：《生物医学工程学杂志》1999年第3期295-299,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金

摘　　要：研究了雌性山羊切除双侧卵巢后不同时间骨生物力学性能的变化。２ 岁左右雌性成都山羊１４ 只，体重２８±３ｋｇ，随机分为双侧卵巢切除（ＯＶＸ）半年组４ 只、ＯＶＸ １ 年组５ 只、ＯＶＸ １ 年半组５ 只。术后半年、１ 年、１ 年半处死动物，取出右侧股骨、胫骨、跖骨。用三点弯曲法测定股骨整体骨弯曲结构力学参数的变化；用跖骨测定整体骨压缩结构力学参数的变化；分别取股骨和胫骨断端密质骨试件测定弯曲、压缩、拉伸的材料力学参数的变化。结果显示：ＯＶＸ １ 年组与ＯＶＸ 半年组相比，骨的几何参数均减小；股骨整体骨三点弯曲弹性模量减小２３．２７％ ，而破坏荷载和极限强度则无明显变化（Ｐ＞ ０．０５）；股骨和胫骨骨试件的弯曲、压缩和拉伸实验中，除胫骨弯曲、压缩和拉伸的极限强度明显降低（Ｐ＜ ０．０５）外，其余参数降低不明显（Ｐ＞ ０．０５）。ＯＶＸ １ 年半组与ＯＶＸ １ 年组相比，股骨的骨厚度和胫骨的矢状径、冠状径和骨厚度增加明显（Ｐ＜ ０．０５）；股骨整体骨三点弯曲的破坏荷载增高明显（Ｐ＜ ０．０５），这可能与ＯＶＸ １ 年半组体重增加相关；股骨和胫骨骨试件的压缩极限强度和弹性模量及胫骨骨试件弯曲的弹性模量明显减小（Ｐ＜ ０．０５）。This paper presents the changes of biomechanical properties in goats at different times after ovariectomy. 14 goats were randomly divided into three groups. These goats were ovariectomized and sacrificed at 180 days(n=4),360 days(n=5) and 540 days(n=5) after the operation.The right femur, tibia and metatarsus were taken out. The structure mechanical properties of femora were measured with the three point bending method and those of metatarsus were measured with the compressing method. The material mechanical properties of flexure, compress and tensile strength in the compact bone specimens of femora and tibiae taken from broken ends were also measured. The results showed that the one year group, compared with the half year group, had all the bone geometric parameters decreased, but not statistically significant ( P>0.05) ; the elastic modulus of three point bending of femora decreased by 23.27% and the others had no significant difference( P>0.05) ; all the material parameters of flexurel, compress and tensile strength in compact bone specimens decreased, but only the ultimate strength of tibiae of flexure, compress and tensile strength decreased obviously ( P<0.05) . The one and a half year group, compared with the one year group, had the bone density of femora and tibiae decreased, but not statistically significant ( P>0.05) . All the bone geometric parameters of tibiae and the thickness of bone of femora increased ( P<0.05) .The break load of three point bending of femora increased ( P<0.05) . Probably,it was related to the increase of the body weight in the one and a half year group. The elastic modulus and the ultimate strength decreased, but not statistically significant ( P>0.05) . When compact bone specimens were used, the ultimate strength and elastic modulus of femora and tibiae in compress and the elastic module of tibiae in flexure decreased obviously ( P<0.05) ;and the others had no significant changes ( P>0.05) . This study indicated that the degree of osteoporosis in ovarie

关 键 词：山羊 生物力学 骨质疏松 去卵巢 雌性 

分 类 号：R588.06[医药卫生—内分泌] R681[医药卫生—内科学]