5-芳基-3-羟基异噁唑的合成  

Synthesis of 5-aryl-substituted-3-hydroxy-isoxazoles

作　　者：李阳[1] 黄翔[1] 陈达[1] 龚占强[1] 巨修练[1] 

机构地区：[1]武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室,湖北武汉430074

出　　处：《武汉工程大学学报》2011年第5期18-21,共4页Journal of Wuhan Institute of Technology

摘　　要：以不同取代的苯甲醛为起始原料,经wittig反应,溴加成,关环得到5-芳基-3-异噁唑醇.报道了对5个5-芳基-3-羟基噁唑化合物的新合成路线,这些目标化合物结构均经1H NMR和MS表征.并对化合物的wittig反应机理和关环反应机理进行了讨论.Five 5–aryl-substituted-3-hydroxy-isoxazoles were synthesized from aromatic aldehydes by means of wittig reaction,bromide reaction,and cyclization.All of the target compounds have been confirmed by 1H NMR,MS spectrums and elementary analysis.In addition,the possible mechanism of wittig reaction and the cyclization route was discussed.

关 键 词：异噁唑 合成 杂环化合物 

分 类 号：O626.13[理学—有机化学]