中药石斛对大鼠胃热证的作用研究  

Effect study of dendrobium in traditional Chinese medicine on stomach-heat syndrome in rats

作　　者：黄雪群[1] 李续娥[2] 黄彩珠 

机构地区：[1]清远职业技术学院食品药品系,广东省清远市511510 [2]华南师范大学生命科学学院,广州市510631 [3]清远职业技术学院护理学院,广东省清远市511510

出　　处：《临床合理用药杂志》2011年第10期4-6,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨中药石斛对胃热证大鼠全身体征及胃部生理机能的影响。方法 120只SD大鼠随机分为空白对照组1、空白对照组2、模型对照组1、模型对照组2、黄连大剂量组、黄连小剂量组、石斛大剂量组、石斛小剂量组各15只。用1.0kg/L的干姜以5mg/kg剂量灌胃大鼠连续15d制成胃热证大鼠模型,对石斛大、小剂量组应用不同剂量进行治疗,对黄连大、小剂量组应用不同剂量进行治疗,观察石斛大、小剂量对大鼠全身体征及胃部生理机能的影响。结果造模后模型对照组1、模型对照组2、黄连大剂量组、黄连小剂量组、石斛大剂量组、石斛小剂量组大鼠日平均食量高于造模前,差异均有统计学意义(P<0.05);治疗后黄连大剂量组、黄连小剂量组、石斛大剂量组、石斛小剂量组大鼠日平均食量低于造模后,差异均有统计学意义(P<0.05)。造模后模型对照组1、模型对照组2、黄连大剂量组、黄连小剂量组、石斛大剂量组、石斛小剂量组大鼠日平均尿量低于造模前,差异均有统计学意义(P<0.05);治疗后黄连大剂量组、黄连小剂量组、石斛大剂量组、石斛小剂量组大鼠日平均尿量高于造模后,差异均有统计学意义(P<0.05)。模型对照组大鼠血浆中6-Keto-PGF1α含量低于空白对照组,差异有统计学意义(P<0.05),但TXB2较空白对照组升高不明显,差异无统计学意义(P>0.05),TXB2/6-Keto-PGF1α较空白对照组升高,差异有统计学意义(P<0.05)。治疗后黄连大、小剂量组和石斛大、小剂量组大鼠血浆中6-Keto-PGF1α含量明显高于模型对照组,TXB2和TXB2/6-Keto-PGF1α明显低于模型对照组,差异均有统计学意义(P<0.05)。石斛大、小剂量组TXB2含量和TXB2/6-Keto-PGF1α均高于黄连大、小剂量组,6-Keto-PGF1α含量低于黄连大、小剂量组,差异均有统计学意义(P<0.05)。结论石斛对大鼠胃热证具有治疗作用。Objective To explore the effect of dendrobium on the systemic sign and gastric physiological function of rat with stomach-heat syndrome.Methods 120 SD rats were randomly divided into the blank control group1,blank control group2,model control group1,model control group2,large-dose coptis group,low-dose coptis group,large-dose dendrobium group and low-dose dendrobium group,15 rats of each.1.0kg/L of dried ginger was fed to rats for 15 days by a dose of 5mg/kg in order to make the model of rats with stomach-heat syndrome.The treatment was instituted with different doses in large-dose and low-dose dendrobium group,and the treatment was instituted with different doses in large-dose and low-dose coptis group.Observed the effects of large-dose and low-dose dendrobium on the systemic sign and gastric physiological function in rats.Results After making model the average feed daily of the model control group1,model control group2,large-dose coptis group,low-dose coptis group,large-dose dendrobium group and low-dose dendrobium group were higher than those of the 6 groups before making model,and the differences were statistically significant （P0.05）;After treatment the average feed daily of the large-dose coptis group,low-dose coptis group,large-dose dendrobium group and low-dose dendrobium group were lower than those of the 4 groups after making model,and the differences were statistically significant （P0.05）.After making model the rats＇ average urinary output daily of the model control group 1,model control group 2,large-dose coptis group,low-dose coptis group,large-dose dendrobium group and low-dose dendrobium group were lower than those of the 6 groups before making model,and the differences were statistically significant （P0.05）;After treatment the rats＇ average urinary output daily of the large-dose coptis group,low-dose coptis group,large-dose dendrobium and low-dose dendrobium were higher than those of the 4 groups after making model,and the differences were statistically significant （P0.05）.The

关 键 词：石斛 胃热证 作用研究 大鼠 

分 类 号：R285.5[医药卫生—中药学]