2型糖尿病合并非酒精性脂肪肝患者颈动脉粥样硬化临床分析  

Carotid atherosclerosis in type 2 diabetes mellitus combined with nonalcoholic fatty liver disease

作　　者：胡良凯[1] 孟健[2] 张建民[1] 葛军[2] 孙晓岚[3] 陈建清[1] 戴颖[1] 陈薇敏[1] 

机构地区：[1]上海市杨浦区市东医院消化内科,200438 [2]上海市杨浦区市东医院内分泌科,200438 [3]上海市杨浦区市东医院B超室,200438

出　　处：《中华实用诊断与治疗杂志》2011年第5期436-438,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：上海市杨浦区青年课题基金资助(200809)

摘　　要：目的:探讨2型糖尿病合并非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)患者发生颈动脉粥样硬化的临床特点及危险因素。方法:350例2型糖尿病患者,根据是否合并NAFLD分为2型糖尿病无NAFLD组(A组)164例和2型糖尿病合并NAFLD组(B组)186例,比较2组脂代谢紊乱及颈动脉粥样硬化程度。结果:B组体质量指数、腰围,三酰甘油、总胆固醇、谷氨酸转氨酶及门冬氨酸氨基转移酶水平均高于A组(P<0.05);2组空腹血糖、糖化血红蛋白、糖尿病病程、血压比较差异无统计学意义(P>0.05)。350例患者中188例(53.71%)伴不同程度的颈动脉粥样硬化;B组与A组比较,颈动脉粥样硬化患病率高,颈动脉内膜-中层厚度明显增厚,差异有统计学意义(P<0.05)。结论:2型糖尿病患者NAFLD及颈动脉粥样硬化发病率均较高,合并NAFLD的2型糖尿病患者易发生颈动脉粥样硬化。Objective To investigate the clinical characteristics and risk factors for carotid atherosclerosis in type 2 diabetes mellitus combined with nonalcoholic fatty liver disease.Methods A total of 350 patients with type 2 diabetes mellitus were divided into group A（n=164,not complicated with nonalcoholic fatty liver disease） and group B（n=186,complicated with nonalcoholic fatty liver disease）.The degrees of lipid disorder and carotid atherosclerosis were compared between two groups.Results The levels of body mass index,waist circumference,triacylglycerol,cholesterol,alanine aminotransferase and aspartate aminotransferase were higher in group B than those in group A,which showed significant differences（P0.05）.There were no significant differences in blood glucose,glycosylated hemoglobin,blood pressure and course of diabetes mellitus between two groups（P0.05）.In 350 cases,188 cases（53.71%） were complicated with carotid atherosclerosis disease.The morbidity of carotid atherosclerosis was higher and intima-media thickness was obviously thicker in group B compared with group A（P0.05）.Conclusion The morbidities of carotid atherosclerosis and nonalcoholic fatty liver disease are higher in patients with type 2 diabetes mellitus.Carotid atherosclerosis usually occurs in those with type 2 diabetes mellitus complicated with nonalcoholic fatty liver disease.

关 键 词：2型糖尿病 非酒精性脂肪肝 动脉粥样硬化 动脉内膜-中层厚度 

分 类 号：R587.1[医药卫生—内分泌]