糖尿病肾病患者血清PECAM-1的表达及临床意义  

Expression and clinical significance of serum PECAM-1 in patients with diabetic nephropathy

作　　者：王兴纬[1] 金星进[1] 沈晓伟[1] 奚正荣[1] 陆益龙[2] 巴荣[2] 侯莉[2] 雷艳花[2] 陈霞[2] 

机构地区：[1]南通大学附属妇幼保健院,226006 [2]江苏大学附属医院

出　　处：《江苏医药》2011年第10期1164-1165,共2页Jiangsu Medical Journal

基　　金：南通市社会发展基金项目(S2007023)

摘　　要：目的探讨糖尿病肾病(DN)患者血清血小板内皮细胞黏附分子1(PECAM-1)的表达及其临床意义。方法 ELISA法检测20例DN患者(DN组)血清PECAM-1,高效液相法检测糖化血红蛋白(HbA1c),生化法检测血糖(Glu),全血细胞分析仪测定血小板计数(Plt);其结果与19例2型糖尿病患者(T2DM组)及16例正常人(C组)比较。结果 DN组PECAM-1、Glu、HbA1c水平高于C组(P<0.01)。T2DM组PECAM-1与Glu、HbA1c水平呈正相关(P<0.01),Glu与HbA1c水平呈正相关(P<0.05)。结论血清PECAM-1高表达是促进T2DM患者血管内皮细胞内皮损伤和肾功能损害的重要因素;血清PECAM-1水平可作为该类疾病治疗效果评价及并发症发生的预测指标。Objective To investigate the changes of serum concentrations of platelet endothelial cell adhesion molecule-1（PECAM-1）in type 2 diabetic mellitus（T2DM） patients with diabetic nephropathy（DN）.Methods Serum PECAM-1,blood glucose（Glu）,glycosylated hemoglobin A-1c（HbA1c） and platelet count（Plt） were examined in 20 DN patients（group DN）,19 T2DM patients（group T2DM） and 16 healthy persons（group C）.Results The levels of PECAM-1,HbA1c and Glu were higher in group DN than those in group C（P0.01）.In group T2DM,serum level of PECAM-1 was positively correlated to the levels of HbA1c and Glu（P0.01） and Glu was positively correlated with HbA1c（P0.05）.Conclusion High expression of PECAM-1 is an important factor to promote the injury of vascular endothelial cells and renal function in T2DM patients.Detection of serum PECAM-1 can be taken as a marker in evaluating clinical therapeutic efficacy and predicting prognosis of T2DM patients.

关 键 词：2型糖尿病 糖尿病肾病 血小板内皮细胞黏附分子1 

分 类 号：R589[医药卫生—内分泌]