基于数据挖掘的急性脑梗死血压、体温联动变化与毒损脑络证候特点相关性分析  

Correlation between syndrome characteristics of brain collateral damaged by internal toxin and blood pressure-temperature ganged fluctuation of acute cerebral infarction based on data mining

作　　者：张志辰[1] 张允岭[1] 曹晓岚[2] 张玉莲[3] 赵建军[4] 陈志强[5] 常富业[6] 郑宏[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]山东中医药大学附属医院 [3]天津中医药大学第二附属医院 [4]长春中医药大学第一附属医院 [5]河北医科大学中医院 [6]煤炭总医院

出　　处：《北京中医药大学学报》2011年第5期309-312,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家科技部973计划项目(No.2006CB504805)

摘　　要：目的探讨急性脑梗死患者的血压、体温联动变化与中医四诊信息变化规律,借助四诊信息组合规律发现其证候特点。方法动态采集急性脑梗死患者的体温、血压、中医四诊信息及NIHSS评分。对采集数据分别进行相关性分析、建立Logsitic回归方程、主成分分析,并根据其分值,计算综合评价分数,进行动态比较。结果体温升高、血压骤变的联动变化与NIHSS评分具有相关性;昏瞀、言语謇涩或不语、目眵多秽等症状群的四诊信息与体温、血压联动变化密切相关;主成分分析显示,各主成分所占比例,主成分1(昏瞀、呼吸急促、口臭疾脉、面色晦暗)占34.655%,主成分2(不语、目眵多糊、痰色黄)占16.575%,主成分1、2合计占51.23%,按公式(主成分1×34.655%+主成分2×16.575%)÷51.23%计算综合评价分数,结果在脑梗死急性期的3～5 d,主成分综合评价分数从负值变为正值,此症状群的四诊信息变化最为剧烈,该症状群的四诊信息具有一定敏感性与特异性。结论以血压骤变与体温升高联动变化为分层依据,动态采集的四诊信息部分反映了毒损脑络中的火毒证的证候特点,该症状群的四诊信息剧烈变化的时间出现在入院后的3～5 d。Objective To investigate the change laws of blood pressure-temperature ganged fluctuation and TCM four examination information in the patients with acute cerebral infarction（ACI）,and find out its syndrome characteristics.Methods The information of body temperature,blood pressure,TCM four examinations and NIHSS scores were collected dynamically from the patients.The correlation among the data was analysed,logistic regression equation and principal component analysis（PCP） were set up,and the score values of them were compared dynamically.The scores of comprehensive evaluation were counted.Results There was a correlation between blood pressure-temperature ganged fluctuation（increase of temperature and sudden changes of blood pressure） and NIHSS scores.The information of TCM four examinations in a group of symptoms（coma,dysphasia or aphasia and mucopurulent eye secretion） were closely related to the blood pressure-temperature ganged fluctuation.The results of PCP showed that the proportion of all principal components as follows： pricipal component 1（coma,polypnea,bad breath,swift pulse and dull complexion） accounted for 34.655%,principal component 2（aphasia,mucopurulent eye secretion and yellow sputum）,16.575%,and total proportion of component 1 and 2,51.23%.The scores of comprehensive evaluation were counted according to the equation of（principal component 1×34.655%＋principal component 2×16.575）÷51.23%,and the result showed that the scores of comprehensive evaluation of principal components changed from negative value to positive value.The information of TCM four examinations changed most radically on the 3rd to 5th day of ACI with different endpoints.The changes of the information of TCM four examinations were different with sensitivity and specificity in this group of symptoms.Conclusion The information of TCM four examinations collected dynamically reflects the characteristics of fire-toxin syndrome of brain collateral damaged by internal toxin taken pressure-temperature ganged

关 键 词：数据挖掘 四诊信息 复杂系统 毒损脑络 

分 类 号：R255.2[医药卫生—中医内科学]