降糖通痹散治疗糖尿病周围神经病变30例  

Treating 30 Cases of Diabetic Peripheral Neuropathy with Hypoglycemic Tongbi Powder

作　　者：翟立华[1] 

机构地区：[1]河南省中医药研究院附属医院,河南郑州450004

出　　处：《实用中医内科杂志》2011年第5期86-88,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察在西医治疗方法基础上联合自拟降糖通痹散治疗糖尿病周围神经病变(DPN)的疗效。[方法]将符合2型糖尿病并伴不同程度周围神经病变的患者60例,随机分为治疗组和对照组各30例,在饮食控制和降糖药物治疗基础上,对照组口服维生素B1和甲钴胺片治疗,治疗组在对照组治疗基础上加用中药降糖通痹散治疗,两组连续用药4周,观察两组治疗后临床疗效、治疗前后临床表现积分、治疗前后运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)变化、胰岛素样生长因子-1(IGF-1)水平。[结果]治疗组总有效率为90%,对照组总有效率为73.3%,治疗组优于对照组(P<0.05);两组治疗后积分均明显下降,和治疗前做比较,治疗组优于对照组(P<0.01);两组治疗后运动神经与感觉神经传导速度比较,治疗组优于对照组(P<0.05或P<0.01);两组治疗后均可升高胰岛素样生长因子-1,治疗组优于对照组(P<0.05)。[结论]降糖通痹散配合西药治疗DPN疗效显著。[Objective]To observed the efficacy of the treatment on Diabetic peripheral neuropathy based on the western medicine combined with self institute Hypoglycemic Tongbi powder.[Methods]60 patients with Type 2 Diabetes were randomly divided into the treatment group and the control group and each group were 30 patients.Based on the died control and hypoglycemic drugs cure,the control group were treated with Vitamin B2 and Mecobalamin tablets,the treatment group were treated with Vitamin B2 and Mecobalamin tablets.Both groups were used the drugs for 4 weeks,to observed the cure effect,clinical manifestations integral,the change of motor nerve conduction velocity and Sensory nerve conduction velocity before and after treatment,the level of the Insulin-like growth factor-1.[Results]90% of treatment group had effects,73.3% of control group had effects,there were significant differences（P0.05）treatment group better than the control group;the integral of 2 groups were clearly decreased after treatment,compared with the situation before treatment.there were significant differences（P0.01）treatment group better than the control group;the compared between motor nerve conduction velocity and Sensory nerve conduction velocity of 2 groups,there were significant differences（P0.05 or P0.01）treatment group better than the control group;the 2 groups both increase the Insulin-like growth factor-1,there were significant differences（P0.05）treatment group better than the control group.[Conclusion]Hypoglycemic Tongbi powder combined with western medicine to treatment Diabetic peripheral neuropathy has Significant treatment effect.

关 键 词：糖尿病周围神经病变 降糖通痹散 临床观察 

分 类 号：R255.4[医药卫生—中医内科学]