妊娠糖尿病使用门冬胰岛素与普通人胰岛素治疗对围产期影响的临床研究  

Gestational diabetes using insulin aspart and insulin therapy on perinatal ordinary clinical study on effects

作　　者：蒋红[1] 吴艳[1] 李康[2] 喻荷淋[1] 朱晓荣[1] 刘阳[1] 陈诚[1] 蒋莉[1] 潘慧[2] 

机构地区：[1]四川省遂宁市中心医院,四川遂宁629000 [2]中国医学科学院北京协和医院内分泌科,北京100730

出　　处：《中国卫生检验杂志》2011年第5期1061-1062,1066,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:比较胰岛素类似物门冬胰岛素与普通人胰岛素治疗妊娠糖尿病妇女的围产期结果。方法:将62例新诊断的饮食控制不达标的妊娠糖尿病妇女随机分为使用门冬胰岛素治疗组(Asp组)及使用普通人胰岛素治疗组(HI组),观察分娩时胰岛素用量(U/(kg.d))、羊水量(ml)、胎儿出生时体重(g)和身长(cm)、以及空腹及餐后血糖(mmol/L)、低血糖事件发生数等指标。结果:①Asp组分娩时羊水量显著低于HI组(417.0±13.2 ml vs 989.7±29.3 ml;P<0.05);同时Asp组餐后血糖显著低于HI组(6.5±0.4 mmol/L vs 9.3±1.5 mmol/L;P<0.05)。Asp组总计发生低血糖事件数为58次,而HI组总计发生低血糖事件数为203次。②羊水量与餐后血糖控制程度有正相关关系(r=0.72,P<0.05)。结论:门冬胰岛素能很好的控制餐后血糖,减少围产期羊水过多、巨大儿等风险,且能减少低血糖事件。Objective：To assess the results of insulin aspart in comparison with regular human insulin in women with gestational diabetes mellitus（GDM） during perinatal stage.Methods： 62 women with newly diagnosed GDM who had inadequate diabetes control with diet alone were randomly divided into two groups,and they were received therapy with aspart insulin or human insulin.Insulin doses,the volume of amniotic fluid,weight and length of neonates,fasting plasma glucose and postprandial plasma glucose,hypoglycemia were recorded during childbirth.Results： ① The volume of amniotic fluid in aspart group was significantly lower than that in HI group（417.0±13.2 ml vs 989.7±29.3 ml;P〈0.05）.Postprandial plasma glucose was significantly lower in aspart group than that in HI group（6.5±0.4 mmol/L vs 9.3±1.5 mmol/L;P〈0.05）.All hypoglycemia episode in aspart group and human insulin group were 58 and 203 respectively.② The volume of amniotic fluid was related with postprandial glucose（r= 0.72,P〈0.05）.Conclusion： Aspart was more effective and safer than human insulin.

关 键 词：妊娠糖尿病 门冬胰岛素 围产期 

分 类 号：R714.25[医药卫生—妇产科学]