微量元素的检测在糖尿病及糖尿病肾病中临床意义  

The significance of the trace elements in patients with diabetes and diabetic nephropathy

作　　者：梅丽萍[1] 孙星达[1] 齐娟飞[1] 王静[1] 麻微微[1] 

机构地区：[1]台州医院检验科,浙江临海317000

出　　处：《中国卫生检验杂志》2011年第5期1198-1200,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨四种微量元素铜(Cu)、锌(Zn)、铁(Fe)、铬(Cr)与糖尿病(DM)及糖尿病肾病(DN)之间的关系,研究微量元素在DM发生、发展中的作用。方法:同时测定98例DM患者,DM、DN肾功能正常组53例,DM、DN肾功能不全组33例,正常对照组60例的微量元素铜(Cu)、锌(Zn)、铁(Fe)、铬(Cr)的值及肌酐(Cr)、尿素(BUN)、胱抑素C(Cy-sC)及内生肌酐清除率(CCr)的值。结果:DM组与对照组比较,铜高于正常对照组,锌、铁、铬低于正常对照组(P<0.05)。微量元素与血糖的相关性,除铜是正相关,锌、铁、铬均为负相关。DN肾功能不全组和DN肾功能正常组锌、铁、铬均低于正常对照组,铜高于正常对照组(P<0.05);DN肾功能不全组锌、铁均低于DN肾功能正常组(P<0.05)。结论:微量元素的检测,对DM的发生、发展,有效的预防并发症DN的发生,有一定的临床意义。Objective：To discuss the relationship between diabetes,diabetic nephropathy and the trace elements levels,and to research the role of the trace elements in diabetes development.Methods： Human blood trace elements（copper,zinc,iron,chrome） and the serum creatinine,BUN,cystatin C and creatinine clearance were tested in 98 cases of DM,53 cases of DN and renal function normal,33 cases of DN and renal inadequacy,and 60 normal control.Results： The copper level in diabetes was significantly higher than healthy controls,and the zinc,iron,chrome level in diabetes was significantly lower than healthy controls.The copper level and glucose was positive correlation,the zinc,iron,chrome level and glucose was negative correlation.The zinc,iron,chrome level in diabetic nephropathy renal was significantly lower than healthy controls,and the copper level in diabetes was significantly higher than healthy controls.The zinc,iron level in DN and renal inadequacy was significantly lower than DN and renal function normal.Conclusion： There are clinical significance to measure trace elements in the diabetes and diabetic nephropathy.

关 键 词：微量元素 肾功能 糖尿病 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]