慢性乙型肝炎患者肝组织免疫组化表达与血清HBVDNA、HBeAg的关系  

Relationship of liver tissue immunohistochemical and serum HBVDNA,HBeAg with Chronic hepatitis B patients

作　　者：周婧玮[1] 张永乐[1] 李冰茹[1] 黄从想[1] 吴晓星[1] 

机构地区：[1]杭州市第六人民医院,杭州310014

出　　处：《中国卫生检验杂志》2011年第5期1207-1208,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨慢性乙型肝炎患者肝组织免疫组化表达与血清HBV DNA、HBeAg的关系。方法:检测120例慢性乙型肝炎患者外周血HBV DNA、HBeAg含量,同时观察肝组织内免疫组化检测HBsAg、HBcAg的表达,并分析二者之间的关系。结果:120例慢乙肝患者血清HBsAg全阳性,HBeAg阳性58例,HBVDNA阳性72例,肝组织内免疫组化HBsAg阳性120例,HBcAg阳性64例,各组间比较差别均有统计学意义(P<0.05)。结论:慢性乙型肝炎病毒复制指标血清HBV DNA、HBeAg及肝组织内HBcAg中HBcAg表达更能反映出肝内乙肝病毒复制状况。Objective：To investigate the relationship of liver tissue immunohistochemical and serum HBVDNA,HBeAg with Chronic hepatitis B patients.Methods： Detection 120 patients with chronic hepatitis b patients peripheral blood HBVDNA,HBeAg content,and observe the liver tissue inside immunohistochemical detection HBsAg HBcAg expression,and analyzed the relation between the two.Results： 120 patients with CHB patients serum HBsAg HBeAg positive all positive,58 cases of HBVDNA positive,72 cases,liver tissue inside immunohistochemical HBsAg positive 120 example,HBcAg positive 64,each group there were statistically significant differences between the comparison group（P〈0.05）.Conclusion： Chronic hepatitis b virus replication index serum HBVDNA,and hepatic HBeAg within the organization in HBcAg HBcAg expression more can reflect intrahepatic HBV replication condition.

关 键 词：病毒性肝炎乙型 HBVDNA HBEAG 肝组织 免疫组化 

分 类 号：R512.62[医药卫生—内科学]