尿系列微量蛋白测定在儿童肾脏损伤中的意义  

The significance of urinary serial micro-protein detection on renal injury in children

作　　者：朱丽丹[1] 钱茜茜[1] 温怀凯[1] 

机构地区：[1]浙江省温州医学院附属第二医院检验科,浙江温州325000

出　　处：《中国卫生检验杂志》2011年第5期1233-1234,1236,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨尿系列微量蛋白检测在儿童(<13岁)肾脏损伤中的意义。方法:选取尿路感染患儿60例、急性肾小球肾炎患儿60例、过敏性紫癜性肾炎患儿70例、原发性肾病综合征患儿80例及正常儿童30例,采用速率散射比浊法检测尿微量白蛋白、免疫球蛋白G、α1-微球蛋白、转铁蛋白含量,采用微粒子酶免法检测尿β2-微球蛋白含量。结果:除急性肾小球肾炎组的α1-M,尿路感染组的IgG、α1-M、TRF与正常对照组比较差别无统计学意义(P(0.05)外,各组别其余项目与正常对照组比较差别均有统计学意义(除过敏性紫癜性肾炎组的α1-MP<0.05外,其余均P<0.01);117例尿蛋白定性阴性的患儿尿系列微量蛋白检出阳性47例,阳性率为36.75%。结论:尿系列微量蛋白测定可用来判断儿童早期肾损害。Objective：To explore the significance of urinary serial micro-protein detection on renal injury in children（13 years old）.Methods：Select respectively 60 cases with urinary tract infection,acute glomerulonephritis,70 cases with Henoch-Schonlein purpura nephritis,and 80 cases with primary nephrotic syndrome and 30 cases normal control children.Rate nephelometry was used to detect urine Micro-albumin,immunoglobulin G,α1-microglobulin,transferrin contents.urine β2-microglobulin was determined by Microparticle enzyme assay.Results： The α1-M in acute glomerulonephritis group,IgG,α1-M,TRF in urinary tract infection group has no statistical significance compare to normal control group（P﹥0.05）,the rest all have a significant difference when compare to normal control group（P〈0.05）.The positive rate of detection urinary serial micro-protein was 36.75% in children with a negative qualitative urine protein.Conclusion：The detection of urinary serial micro-protein can be used to determine early renal injury in children.

关 键 词：肾损伤 尿微量蛋白 儿童 

分 类 号：R692[医药卫生—泌尿科学]