浙江舟山群岛居民甲状腺功能减退症患病情况调查  

The investigation of the prevalence of hypothyroidism in Zhoushan archipelago

作　　者：竺王玉[1] 刘晓光[1] 周世权[1] 王晔恺[1] 胡晓斐[1] 赵臣银[1] 张永奎[1] 

机构地区：[1]浙江省舟山医院细胞分子生物学实验室,浙江舟山316004

出　　处：《中国卫生检验杂志》2011年第5期1252-1254,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家星火计划项目(2008GA700174);浙江省科技厅面上项目(2008C33043)

摘　　要：目的：调查浙江舟山群岛各地区甲状腺功能减退症（简称甲减）患病情况及相关致病因素。方法：对舟山海岛地区1389名城镇居民、502名农民、737名盐民、362名渔民及294名普陀山僧侣进行流行病学问卷调查、血清人促甲状腺激素（hTSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、甲状腺过氧化物酶抗体（TPOAb）和尿碘测定。8岁-10岁儿童仅行尿碘检测。结果：舟山海岛地区城镇居民、农民、盐民、渔民及普陀山僧侣的尿碘中位数（MUI）分别为320.7μg/L、188.9μg/L、122.2μg/L、193.6μg/L和271.7μg/L,亚临床甲减的患病率分别为1.01%、0.80%、0.81%、1.66%、1.36%,仅有1例调查对象患有临床甲减。女性较男性更易患甲减,TPOAb阳性者患甲减危险性较高（P〈0.05）。结论：舟山海岛地区碘营养充足,需警惕自身免疫性甲减的发生。Objective：To investigate the prevalence of hypothyroidism and explore its associated risk factors in various regions in Zhoushan archipelago.Methods： All the residents in Zhoushan archipelago,including 1389 urban residents,737 salt-makers,362 fishers and 294 buddhist in Putuo Mountain,were surveyed by questionnaire and detected their serum human thyroid stimulating hormone（hTSH）,free triioidothyronine 3（FT3）,free thyroixine（FT4）,thyroid peroxidase antibody（TPOAb） and urinary iodine.Results： The median levels of urinary iodine of urban residents,famers,salt-makers,fishers,buddhist were 320.7 μg/L,188.9 μg/L,122.2 μg/L,193.6 μg/L and 271.7 μg/L respectively,while the prevalence rates of subclinical hypothyroidism were1.01%,0.80%,0.81%,1.66% and 1.36%;there was only one residents suffered from hypothyroidism.Female and the one TPOAB-positive had the higher risk for suffering from hypothyroidism（P〈0.05）.Conclusion： The residents in Zhoushan Archipelago has an adequate iodine in-take,but should guard against the occurrence of autoimmune hypothyroidism.

关 键 词：碘 甲状腺功能减退 海岛 流行病学 

分 类 号：R581.2[医药卫生—内分泌]