乙肝病毒前S1抗原与亲缘传播的慢性HBV感染之间的相关研究  

Expression of pre-S1 antigen in chronic HBV patients with family history

作　　者：骆淑雅[1] 陈湖光[1] 

机构地区：[1]浙江大学医学院附属第一医院传染病诊治国家重点实验室,杭州310003

出　　处：《浙江医学》2011年第5期675-677,共3页Zhejiang Medical Journal

摘　　要：目的 为研究亲缘传播造成慢性持续性乙型肝炎病毒（HBV）感染的机制,进行HBV前S1抗原与亲缘传播的慢性HBV感染之间的相关研究.方法 采用时间分辨免疫荧光法对202例慢性HBV感染患者进行血清HBV前S1抗原检测,同时,调查其家族史.结果 有明确家族史178例,其中血HBV前S1抗原阳性115例（64.61%）;而明确无家族史的24例患者中,血HBV前S1抗原阳性者仅8例（33.33%）,两组差异有统计学意义（P＜0.05）.结论 有明确家族史的慢性HBV感染患者血清HBV前s1抗原阳性率较高.Objective TO investigate the expression of HBV pre-S1 antigen in chronic HBV patients with family history. Methods Blood samples were collected from 202 patients with chronic HBV infection, pre-S1 antigen was detected by IFMA method and the family history of the patients were investigated, Results Of 202 patients 178 had family history and 24 had no family history. The pre-S1 positive rate in patients with family history was 64.61% （115/178）, while that in patients without family history was 33.33% （8/24） （P〈0.05）, Conclusion PreS1 antigen has significant correlation with chronic HBV infection transmitted within family.

关 键 词：前S1抗原 HBV 亲缘传播 慢性HBV感染 

分 类 号：R446.62[医药卫生—诊断学]