母乳脂联素浓度变化与婴儿生长发育的相关性研究  

Variation of maternal milk adiponectin and its correlation with infant growth

作　　者：王艳艳[1] 张卓君[1] 姚文[1] Ardythe Morrow 彭咏梅[1] 

机构地区：[1]复旦大学附属儿科医院儿童保健科,上海201102 [2]不详

出　　处：《中华儿科杂志》2011年第5期338-343,共6页Chinese Journal of Pediatrics

基　　金：美国儿童健康与人类发展国立研究所资助项目（HD13021）

摘　　要：目的 分析母乳脂联素（adiponectin,APN）浓度变化,探讨其与婴儿血APN的相关性,及其与0～1岁婴儿生长发育的关系.方法 选择2008年3-12月在上海国际和平妇婴保健院出生的健康足月儿及其母亲73对入组.收集母亲产后2、4、l3、26周母乳,用ELISA法测定母乳APN浓度.分析母乳APN浓度变化趋势及其与婴儿体格生长指标的关系,并运用多元回归方法分析与婴儿生长指标相关的影响因素.且于出生26周时收集婴儿血标本,探讨母乳APN与婴儿血APN的相关性.结果 产后2、4、13、26周母乳APN浓度分别为：14.62（5.93～140.40）、7.32（2.04～29.35）、6.84（2.72～15.65）、4.88（1.12～13.38）μg/L.其中产后2周母乳APN与婴儿13、26、52周年龄别体重Z分值（WAZ）均呈负相关（P＜0.05）;4周母乳APN与婴儿4、13、26、52周WAZ、身长别体重Z分值（WLZ）、体重指数Z分值（zBMI）均呈负相关（P＜0.05）;13周母乳APN与婴儿13、26、52周WAZ、WLZ、zBMI均呈显著负相关（P＜0.01）;26周母乳APN与婴儿52周WAZ、WLZ、zBMI呈负相关关系（P＜0.05）.多元线性回归分析发现母乳APN均为13、26及52周WAZ、WLZ、zBMI最重要的影响因素.婴儿26周血APN与13、26周母乳APN呈正相关（P＜0.05）.结论 随泌乳期的延续,母乳APN浓度呈下降趋势.母乳中APN浓度越高,婴儿体重则明显偏低.婴儿血APN与母乳APN显著相关.Objective To investigate the variation of human breast milk adiponectin （APN）concentration during lactation, analyze the relationship of APN concentrations in human breast milk with APN in infant serum, determine the association between maternal milk APN and infant body proportionality in the first year of life, and the period of greatest human milk exposure.Method Subjects included 73mother-infant pairs from Shanghai International Peace Maternity ＆ Child Health Hospital.Maternal milk was collected at 2, 4, 13, 26 weeks and infant serum was collected at 26 weeks.The concentration of APN in maternal milk and infant serum were measured with commercially available ELISAs （R＆D Systems）.Weight-for-age Z-scores （WAZ） , length-for-age Z-scores （ LAZ ） , weight-for-length Z-scores （ WLZ ） and body mass index Z-scores （ zBMI ） of infants up to 1 year of age were calculated using World Health Organization （WHO） standards.Then the variation of maternal milk APN was investigated, the correlation between maternal milk APN and infant serum APN was analyzed; multivariate regression analysis was used to analyze covariates correlated with infant body proportionality, meanwhile determined the association between maternal milk APN and infant anthropometrics.Result The concentration of APN in maternal milk at 2, 4,13, 26 weeks was respectively （14.62 μg/L, 5.93-140.40 μg/L）, （7.32 μg/L, 2.04-29.35 μg/L）,（6.84 μg/L, 2.72-15.65 μg/L） and （4.88 μg/L, 1.12-13.38 μg/L）.Higher milk APN in postpartum 2weeks was associated with lower infant WAZ at 13, 26 and 52 weeks （ P ＜ 0.05 ）.Milk APN in postpartum 4 weeks was inversely related to infant WAZ, WLZ, zBMI at 13, 26 and 52 weeks （ all P ＜ 0.05 ）.Meanwhile, milk APN in postpartum 13 weeks had significantly negative correlation with infant WAZ, WLZ,zBMI at 13, 26 and 52 weeks （P＜0.01）.Milk APN in postpartum 26 weeks also was inversely associated with infant WAZ, WLZ and zBMI at 52 weeks （P ＜0.05）.After adjusting c

关 键 词：脂联素 乳 人 体重与身体测量 婴儿 

分 类 号：R174[医药卫生—妇幼卫生保健]