整合素亲和力调控的机制  

The Mechanism of Integrin Affinity Regulation

作　　者：潘有东[1] 张坤[1] 岳姣[1] 陈剑峰[1] 

机构地区：[1]中国科学院分子细胞生物学重点实验室,生物化学与细胞生物学研究所,中国科学院上海生命科学研究院,上海200031

出　　处：《中国细胞生物学学报》2011年第5期457-465,共9页Chinese Journal of Cell Biology

基　　金：973国家重点基础研究发展计划(No.2010CB529703);国家自然科学基金(No.30970604;No.30700119)资助项~~

摘　　要：整合素是一类重要的细胞表面粘附分子,是由α和β两个亚基组成的异源二聚体跨膜蛋白。整合素作为细胞内外的桥梁,一方面负责介导细胞与细胞、细胞与细胞外基质以及细胞与病原体的相互作用,另一方面可以双向传递跨膜信号,对于免疫反应、免疫细胞的组织定位、凝血、组织愈伤、癌细胞转移以及组织和器官的发育等都至关重要。整合素与配体的结合及其相关的信号转导是受到精确调控的,这个过程伴随着整合素的一系列构象变化。整合素的另外一个特性是其与配体的结合受到二价金属阳离子的调控。本文重点介绍了整合素功能与构象的关系以及金属离子调控整合素功能的分子机制。Integrins are a family of α/β heterodimeric cell adhesion molecules that mediate cell-cell, cell- matrix and cell-pathogen interactions. They transmit signals bidirectionally across the plasma membrane and play key roles in development, immune responses, leukocyte trafficking, hemostasis, and cancer. The ligand binding affinity and signaling of integrin are regulated dynamically and precisely by different stimuli, and are associated with the conformational rearrangement of the integrin molecule. Moreover, the receptor function of integrin is regulated by different divalent cations. This article mainly focuses on the relationship between integrin function and its conformation, and the regulation of integrin function by divalent cations.

关 键 词：整合素 构象 亲和力 二价阳离子 信号转导 

分 类 号：Q26[生物学—细胞生物学]