黄芪、人参、西洋参提取物对心肌缺血犬心脏血流动力学的影响  

Influence of Astragalus Mongholicus,Panax Ginseng and Panax Quinquefolium L on Cardiac Hemodynamics in Acute Experimental Myocardial Ischemia Beagle Dogs

作　　者：姜水莲[1] 吕圭源[2] 陈素红[1] 黄敏聪[1] 张丽丹[2] 吴经耀[2] 余芳[2] 

机构地区：[1]温州医学院,浙江温州325035 [2]浙江中医药大学,浙江杭州310053

出　　处：《上海中医药大学学报》2011年第3期80-84,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30801529);国家中医药行业科研专项基金资助项目(2007-12)

摘　　要：目的:观察黄芪、人参、西洋参三味补气中药提取物对急性心肌缺血模型犬心脏血流动力学的影响。方法:将Beagle犬随机分为假手术组、模型组、对照组、黄芪组、人参组、西洋参组。采用结扎冠状动脉前降支法复制Beagle犬急性心肌缺血模型,经右颈总动脉逆行插管依法测量左心室功能。经十二指肠各组给予相应药物。于冠脉结扎15 min(药前)及药后60、90、120、180 min检测心肌收缩功能指标[左心室收缩期压力(LVP)、最大压力上升速度(+dp/dtmax)]、心肌舒张功能指标[左心室舒张期压力(LVEDP)、最大压力下降速度(-dp/dtmax)]、心脏泵血功能指标[心输出量(CO)、总外周阻力(TPR)]。结果:冠状动脉结扎后,模型组犬的LVP、±dp/dtmax、CO明显下降,LVEDP、TPR增加。三种中药提取物均可改善心肌缺血犬心肌舒缩功能,其中增加LVP、+dp/dtmax以黄芪、人参效果较好;降低心肌缺血犬的LVEDP,增加-dp/dtmax以西洋参效果较好;黄芪可增加心肌缺血犬的CO。结论:三味补气中药均可不同程度改善缺血心肌舒缩功能及心脏的泵血功能,但黄芪、人参长于改善缺血心肌的舒缩功能,西洋参长于改善心肌的舒张功能。To investigate the effects of three qi-invigorating herbs （Astragalns Mongholicns, Panax Ginseng and Panax Quiaquefolium L） on the hemodynamics in acute experimental myocardial ischemia Beagle dogs. Methods： Thlrty-slx Beagle dogs were randomly divided into six groups, including sham group, model group, Isosorbide dinitrate group （ID, 0.6mg/kg）, Astragalus monghollcus extract group （AM, 500mg/kg） , Panax ginseng extract group（ PG, 300mg/kg）, Panax quinquefolium L extract group （PQ, 300mg/kg）. The left anterior descending coronary artery was ligated to establish the acute myocardial iscbemia model. The dogs were monitored to evaluate the left ventrieular function. The experimental drugs were duodenally perfused. The parameters of cardiac hemodynamics were determined before and after administration. Results： After coronary ligation, the±dp/dtm=, LVP and CO were reduced obviously whereas LVEDP and TPR were increased significantly in model group. The extracts of all the three herbs could improve the systolic and diastolic function in myocardial ischemia Beagle dogs. The administration of AM extract and PG could increase±dp/dtmax and LVP significantly; PQ could decrease LVEDP and increase -dp/dtmax significantly; AM could increase CO slgnifieaudy. Conclusion： The three qi-invigorating herbs can improve cardiac contraction and distolization and blood pumping; PG and AM excel in improving cardiac contraction and distolizatiou, and PQ excels in improving cardiac diastolization.

关 键 词：急性心肌缺血 心脏血流动力学 补气药 黄芪 人参 西洋参 

分 类 号：R285.5[医药卫生—中药学]