血清骨保护素水平与冠心病患者肺动脉高压的相关性研究  

Correlation of serum osteoprotegerin level with pulmonary hypertension in patients with coronary artery heart disease

作　　者：马晓烨[1] 吕安康[1] 陆林[1] 范小明[1] 吴祁红[1] 杨二丽[1] 许燕[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心脏科,上海200025

出　　处：《诊断学理论与实践》2011年第2期162-165,共4页Journal of Diagnostics Concepts & Practice

基　　金：国家十一.五科技支撑计划重大项目课题"提高肺动脉高压诊治水平的研究"(2006BAI01A07)

摘　　要：目的:评价血清骨保护素(OPG)水平在冠心病合并肺动脉高压中的意义。方法:将70例冠心病患者依据肺动脉收缩压(PASP)分为冠心病合并肺动脉高压组(PASP≥30 mm Hg,23例)和冠心病无肺动脉高压组(PASP<30 mm Hg,47例)。应用超声心动图测定其心功能,并采用酶联免疫吸附试验(ELISA)检测患者血清中的OPG水平。结果:与冠心病无肺动脉高压组相比,冠心病合并肺动脉高压组患者的左心房内径(LAD)、左心室舒张末期内径(LVEDD)、左心室舒张末期容量(LVEDV)和左心室收缩末期内径(LVESD)、左心室收缩末期容量(LVESV)均明显增加(P均<0.05),其中LAD与PASP呈正相关(r=0.736,P<0.001)。同时,冠心病合并肺动脉高压患者的血清OPG水平明显高于冠心病无肺动脉高压者(P<0.05),且其OPG水平与部分左心室指标呈正相关(P均<0.05)。结论:血清OPG水平能反映左心室指标的变化,进而可预测冠心病患者肺动脉高压的发生;与此同时,OPG还可能促使冠心病合并肺动脉高压患者的肺动脉压进一步升高。Objective To assess the significance of serum osteoprotegerin（OPG） level in coronary artery heart disease（CHD） with pulmonary hypertension（PH）.Methods According to pulmonary artery systolic pressure（PASP）,70 patients with CHD were divided into 2 groups： 23 CHD with PH（PASP≥30 mm Hg） and 47 CHD without PH（PASP30 mm Hg）.Echocardiography was performed to assess the heart function.Serum OPG level was measured by ELISA.Results LAD,LVEDD,LVESD,LVEDV,LVESV and serum OPG levels were significantly higher in CHD patients with PH than those in CHD patients without PH（P0.05,respectively）.LAD was correlated significantly with PASP（r=0.736,P0.001）.And serum OPG level was correlated significantly with LVEDD,LVESD,LVEDV and LVESV（P0.05,respectively）.Conclusions Serum OPG level could reflect the changes of LV parameters and predict the development of PH in CHD patients.

关 键 词：骨保护素 冠心病 肺动脉高压 

分 类 号：R541.4[医药卫生—心血管疾病]