镉在大鼠前列腺组织内的蓄积  

Accumulation of cadmium in prostate glands of rats

作　　者：李剑[1] 周仁江 李庆春[1] 王婧[1] 郭磊磊[1] 罗子国[1] 

机构地区：[1]重庆医科大学生命科学院,重庆400016 [2]重庆市九龙坡区第五人民医院,重庆400029

出　　处：《生态科学》2011年第2期170-173,共4页Ecological Science

摘　　要：为比较重金属镉在去势与非去势雄性大鼠前列腺组织内蓄积量的变化,将60只健康雄性SD大鼠随机分为六组:对照组、去势对照组、低剂量镉组(2.5 mμmol·Kg^(-1))、高剂量镉组(20 mμmol·Kg^(-1))、去势低剂量镉(2.5 mμmol·Kg^(-1))组、去势高剂量镉(20 mμmol·Kg^(-1))组,18个月后取材进行实验。利用原子吸收分光光度法检测大鼠前列腺组织中重金属镉含量。与非去势对照组相比,各去势组大鼠前列腺组织内镉含量明显降低;注射镉后,大鼠前列腺组织镉含量明显高于对照组,但高、低剂量组之间无显著差别。实验表明长期镉暴露后,前列腺组织内镉含量明显增加;经去势手术的大鼠,长期镉暴露后前列腺组织内镉含量未升高,但机制并不明确。Abstract： To investigate the change of cadmium accumulation in prostate glands of normal and castrated rats, sixty healthy male adult SD rats were randomly divided into six groups： control group, castration group, low dose cadmium group （2.5 mμmol ·Kg^-1）, high dose cadmium group （20 mμmol · Kg^-1）, castration and low dose cadmium group （2.5 mμmol · Kg^-1 ）, and castration and high dose cadmium group（20 mμmol·Kg^-1）. The prostates of rats were sampled after 18 months of experiment. The cadmium content was measured by using atomic absorption spectrophotometry （AAS）. The results showed that cadmium content in castration groups was significantly decreased than in non-castration groups. It was increased after peritoneal injection, but there was not statistical significance in different cadmium dosage groups. Our results showed that cadmium content was increased by long-term cadmium exposure; while it was not increased in castrated rats after long-term cadmium exposure. The underlying mechanism is not clear.

关 键 词：镉 去势 前列腺 大鼠 

分 类 号：R994.6[医药卫生—毒理学] Q579.11[医药卫生—药学]