预先心理应激对干舱模拟快速上浮脱险大鼠应激反应的作用  

Effects of psychological pretreatment on the stress reaction of the simulated fast buoyancy ascent escape in rats

作　　者：王世锋[1] 方以群[1] 吕传禄[1] 周勇[2] 王淑平 朱嘉[1] 

机构地区：[1]海军医学研究所,上海200433 [2]解放军第四一一医院 [3]海司航保部

出　　处：《中华航海医学与高气压医学杂志》2011年第2期100-101,114,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的观察预先心理应激对大鼠在模拟快速上浮脱险过程中应激反应的影响。方法40只健康雄性SD大按数字随机表法鼠随机等分为4组：对照组、心理应激组、快速加减压组、预先心理应激＋快速加减压组。通过建立快速上浮脱险动物模型，观察预先心理应激对该过程中大鼠应激反应的作用。结果预先进行心理应激的动物在快速上浮脱险过程中，心率明显加快，血清肿瘤坏死因子（TNF-α）表达明显降低。结论心理应激在模拟快速上浮脱险大鼠应激反应中起重要作用。Objective To observe the effects of psychological pretreatment on the stress reaction of simulated fast buoyancy ascent escape in rats. Methods Forty healthy rats were randomly divided into 4 groups： the control group, the psychological stress group, the fast compression and decompression group, and the psychological stress pretreatment plus fast compression and decompression group. By developing the fast buoyancy ascent escape rat model with fast compression and decompression in a closed cabin, the effects of psychological pretreatment on the stress reaction were observed in the course of ascent. Results Heart rate of the animals in the psychological pretreatment stress group was significantly higher than that in the control group （P 〈 0. 05 ） , and the expression of serum TNF-α was significantly lower than that in the control group （ P 〈 0. 05 ）. Conclusions Psychological factor seemed to have positive effects on the stress reaction of the simulated fast buoyancy ascent escape in rats.

关 键 词：快速上浮脱险 预处理 应激反应 心率 肿瘤坏死因子 

分 类 号：R845.2[医药卫生—航空、航天与航海医学]