含碳酸盐氟羟磷灰石—─兔骨内植入的动物试验观察  

INVESTIGATION OF FCHA IMPLANTATION IN RABBIT FEMUR

作　　者：丁宁[1] 赵谌[1] 牛景路[1] 母瑞虹[1] 

机构地区：[1]首都医科大学附属北京口腔医院,100050

出　　处：《北京口腔医学》1999年第4期173-174,共2页Beijing Journal of Stomatology

摘　　要：目的 :通过兔的骨内植入实验观察FCHA的成骨作用。方法 :用新西兰兔作为骨内植入模型 ,术后 2、4周处死。标本经病理切片、HE染色后 ,做组织学观察。结果 :FCHA、HA颗粒对骨的修复作用明显优于空白对照 ,FCHA、HA颗粒周围均有骨组织生成。FCHA周围新生骨的成骨量大于HA。结论 :FCHA、HA均有良好的生物相容性 ,且对骨缺损的修复有促进作用 ,前者的成骨作用明显优于后者。Objective:The role of FCHA was studied in new bone formation by using implantation in rabbit femur Materials and Methods:FCHA is a experimental material implanted in rabbit femur,HA and empty cavity served as control The rabbits were sacrificed in 2 and 4 weeks Histological investigation was performed on decalcified samples Results:The roles of FCHA and HA in new bone formation were obviously more than that of the empty cavity There were newly formed bone tissues around both FCHA and HA,but the amounts of new bone around FCHA were more than that around HA Conclusion:FCHA and HA are of good biocompatibility they can promote the repair of defect bone tissue The role of FCHA was better than that of HA during new bone formation

关 键 词：种植 改性羟磷灰石 动物模型 成骨作用 

分 类 号：R318.08[医药卫生—生物医学工程] R783.1[医药卫生—基础医学]