血小板源性生长因子BB与IgA肾病的关系  

Change of serum platelet derived growth gactor-BB(PDGF-BB)in patients with IgA nephropathy

作　　者：刘翠云[1] 周晓玲[2] 陈孟华[2] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学附属医院肾脏内科

出　　处：《肾脏病与透析肾移植杂志》2011年第2期120-123,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：目的:探讨IgA肾病(IgA nephropathy,IgAN)患者血清中血小板源性生长因子BB(PDGF-BB)与肾脏不同病理改变的关系,旨在寻找一种能反映IgAN肾损害程度的非创伤性临床检测指标。方法:应用酶联免疫吸附法(ELISA)测定92例IgAN患者、30例微小病变性肾病(MCD)患者、30例健康对照的PDGF-BB水平并进行比较;将92例IgAN患者的肾脏病理按Lee氏分级分为A组(Lee氏I级或II级)16例,B组(Lee氏III级)43例,C组(Lee氏IV级或V级)33例,并进行katafuchi半定量评分,观察血清PDGF-BB水平与IgAN不同肾脏病理改变的关系。结果:(1)IgAN患者血清PDGF-BB的含量(746.530±293.012)ng/L明显高于MCD组(208.910±118.56)ng/L及正常对照组(215.320±124.064)ng/L(P<0.05);MCD组(208.910±118.56)ng/L与正常对照组(215.320±124.064)ng/L对比无统计学意义(P>0.05);(2)IgAN者中血清PDGF-BB的浓度C组(926.443±237.162)ng/L明显高于B组(693.103±284.608)ng/L及A组(519.043±198.671)ng/L(P<0.05);同时B组(693.103±284.608)ng/L高于A组(519.043±198.671)ng/L(P<0.05);(3)Pearson相关分析:血清PDGF-BB水平与平均动脉压、血肌酐、24h尿蛋白定量,尿素氮均呈正相关(r=0.353,0.342,0.270,0.261;P均<0.05);与肾小球滤过率呈负相关性(r=-0.414,P<0.05);(4)多元线性回归分析:平均动脉压及Lee氏分级是血清PDGF-BB升高的独立危险因素。结论:血清PDGF-BB浓度可反映IgAN肾脏病理改变的严重程度,可做为IgAN肾损害的非创伤性临床检测指标。Objective ：To investigate the significance of serum platelet derived growth factor-BB （PDGF-BB） in different renal pathology injury of patients with IgA nephropathy. Methodology ： Ninety two patients with IgAN, 30 cases with minimal change disease （MCD） and 30 health adults were enrolled in this study. The serum PDGF-BB was measured by enzyme-linked immunosorbent assay （ELISA） in three groups＇ people. According pathological degree constituted by Lee＇s classifications, all patients with IgAN were divided into five degreesⅠ,Ⅱ,Ⅲ,Ⅳ,Ⅴ, and score for each patient was according to katafuehi semi-quantitative pathological scoring method. Those IgAN patients were divided into three groups： group A （n = 16, Lee-I or II）, group B （n = 43, Lee-m ） and group C （n = 33, Lee-Nor V ）. Results： In IgAN patients, the levels of serum PDGF-BB （747 ng/L ± 2 937 ng/L）were significantly higher than that in MCD（209 ng/L± 119 ng/L）and health subjects（215 ng/L ± 124 ng/L）,P 〈 0. 05. The levels of serum PDGF-BB in group C （926 ng/L±237 ng/L） were significantly higher than that in group A （519 ng/L ±199 ng/L） and B （693 ng/L ± 285 ng/L）, P 〈 0.05, and also significantly higher in group B than that in group A. The correlation analysis indicated the serum PDGF-BB was positively associated with Mean arterial pressure, serum creatinine （SCr）, 24 urine protein, and uric acid respectively, （ r = 0.353,0. 342,0. 270,0.261 ; P 〈 0.05） ; and negatively associated with eGFR （ r = - 0.414, P 〈 0.05 ）. The muhiple regression analysis showed ： the mean arterial pressure and Lee＇s grade were independent dangerous factors of PDGF-BB.Conclusion ： The levels of serum PDGF-BB could reflect the severity of renal injury in human IgAN, so it may be used as a biological mark in prediction of IgAN.

关 键 词：IGA肾病 血小板源性生长因子BB Lee氏分级 katafuchi半定量评分 

分 类 号：R692.3[医药卫生—泌尿科学]