低剂量类固醇吸入合低剂量茶碱口服对哮喘患者肺功能及气道反应性的影响  

The effects of small dose of inhaled beclomethasone dipropionate combined with small dose of oral theophylline on lung function and bronchial responsiveness of asthmatic subjects

作　　者：李靖[1] 罗定芬[1] 安嘉颖[1] 郑劲平[1] 李敏然[1] 欧阳铭[1] 钟南山[1] 

机构地区：[1]广州呼吸疾病研究所,510120

出　　处：《广东医学》1999年第9期663-664,共2页Guangdong Medical Journal

基　　金：受广州市科委科研基金!资助( 编号:96 - Z- 58)

摘　　要：目的　探讨低剂量类固醇吸入加低剂量茶碱口服对轻～中度哮喘病人临床症状、肺功能与气道反应性的影响。方法　Ａ 组２１ 例给予二丙酸培氯松（ＢＤＰ）吸入３００ μｇ／ｄ、加缓释放茶碱片口服２００ ｍｇ／ｄ；Ｂ组２２ 例给予ＢＤＰ吸入６００ μｇ／ｄ， 疗程１３ 周。结果　两组患者的临床症状、第１ 秒用力肺容积（ＦＥＶ１） 及ＦＥＶ１／用力肺活量（ＦＶＣ） 、呼气峰流速值（ＰＥＦ） 及其变异率（ＰＥＦＲ） 和气道反应性（ＰＤ２０） 有显著改善，Ａ组的２５ ％ ～７５％ 、５０％ 及７５％ 用力呼气流速（ＦＥＦ２５％ ～７５％ 、ＦＥＦ５０％ 及ＦＥＦ７５％） 在治疗后均有显著升高， 而Ｂ组则无明显升高。结论　低剂量类固醇吸入配合低剂量茶碱口服与单纯较高剂量类固醇吸入均可改善轻～中度哮喘患者的临床症状、肺功能及气道反应性， 而前者可更有效地改善气道功能。Objective To investigate the effect of small dose of inhaled beclomethasone dipropionate (BDP) and small dose of oral theophylline on lung function and airway responsiveness of asthmatic subjects.Methods 43 patients with mild-moderate bronchial asthma were randomly divided into A and B groups. 21 subjects in group A were treated with oral sustained release theophylline (200 mg/d) and inhaled BDP (300 μg/d), 22 cases in group B were given inhaled BDP (600 μg/d) and oral placebo.Results After 13 weeks of treatment, symptom scores, FEV 1,FEV 1/FVC, PEF, PEFR and PD 20 were significantly improved in both groups. FEF 25%～75% 、FEF 50% and FEF 75% were significantly improved in group A, but not in group B. Conclusion It is suggested that small dose of inhaled BDP combined with small dose of oral theophylline might have the same effect as only high dose of inhaled BDP on clinical symptoms, lung functions and airway responsiveness, and might be more effective on improving airway function.

关 键 词：哮喘 茶碱 气道反应性 呼吸功能试验 类固醇 

分 类 号：R562.25[医药卫生—呼吸系统]