氨杞精口服液对小鼠耐缺氧及抗疲劳作用的实验研究  

Effects of Anqijing Oral Solution on Hypoxia Tolerance and Fatigue Resistance in Mice

作　　者：翟登奎[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150001

出　　处：《中国医院用药评价与分析》2011年第5期450-452,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察氨杞精口服液对小鼠耐缺氧能力和抗疲劳能力的影响。方法:将小鼠随机分为3组,分别为空白对照组、氨杞精口服液低剂量组、高剂量组,连续灌胃给药30 d后,测定小鼠的缺氧存活时间、负重游泳存活时间、血清尿素氮、血乳酸、肝糖原和肌糖原含量等指标的变化。结果:氨杞精口服液可以明显延长小鼠缺氧存活时间,并延长小鼠负重游泳持续时间,降低血乳酸、血清尿素氮含量,提高肝糖原含量和肌糖原含量。结论:氨杞精口服液具有提高小鼠耐缺氧及抗疲劳的作用。OBJECTIVE：To observe the effects of Anqijing oral solution on hypoxia tolerance and fatigue resistance in mice.METHODS：The experimental mice were divided into low-dose Anqijing oral solution group,high-dose Anqijing oral solution group,and control group.After continuous intragastric administration of 30 days,the survival time of mice under hypoxia,loaded swimming endurance time,serum BUN,serum lactate acid,hepatic glycogen and muscle glycogen etc were recorded.RESULTS：Anqijing oral solution significantly prolonged the survival time under the condition of hypoxia and the loading swimming endurance time,down-regulated serum concentrations of both lactate acid and BUN yet up-regulated the concentrations of both hepatic glycogen and muscle glycogen in mice.CONCLUSION：Anqijing oral solution has the action of improving hypoxia tolerance and fatigue resistance in mice.

关 键 词：氨杞精口服液 耐缺氧 抗疲劳 小鼠 

分 类 号：R977.4[医药卫生—药品]