药物对颅脑伤小鼠血糖的影响  

Relationship between the drugs and blood sugar after brain injury in rats

作　　者：路红社[1] 朱诚[2] 张光霁[2] 江基尧[2] 周玉璞[3] 

机构地区：[1]第二军医大学长海医院肿瘤科,上海200433 [2]第二军医大学长征医院神经外科 [3]开封高等医学专科学校淮河医院神经外科

出　　处：《第二军医大学学报》1999年第8期563-564,共2页Academic Journal of Second Military Medical University

基　　金：军队"八五"医学科研规划基金

摘　　要：目的：探讨药物对颅脑伤后血糖水平的影响。方法：采用颅脑外伤液压致伤装置制作颅脑伤动物模型，动态观察药物对血糖水平的影响。结果：（１）地塞米松＋ １０％ 葡萄糖＋ 胰岛素药物组和地塞米松＋ ２０％ 甘露醇＋ 胰岛素组，对颅脑伤后的高血糖具有治疗作用。（２）单纯应用２０％ 甘露醇，在７２ ｈ 内对颅脑伤大鼠具显著的降血糖作用。（３）纳络酮能够显著降低颅脑伤大鼠的血糖含量，给药后２４ ｈ 作用最为显著，７２ ｈ 时仍能维持很好的疗效。结论：甘露醇、纳络酮和适度的ｐ Ｈ 值，对颅脑伤动物具有降血糖作用。Objectve: To study the relationship between the drugs and blood sugar(BS) after brain injury. Methods: The effect of usual drugs which treating brain injury(BI) on BS was observed in rats after head injury.Results: (1)The group of dexamethasonum + 10% glucose + insulin, and the group of dexamethasonum + 20% mannitolum + insulin were effective for treating high BS after drug injection. (2)20% mannitolum was effective for treating high BS after drug injection. (3)Naloxone could markedly decrease BS. Conclusion: The drugs of mannitolum, naloxone and certain pH could decrease blood sugar in brain injury animals

关 键 词：颅脑损伤 血糖 小鼠 药物疗法 

分 类 号：R651.15[医药卫生—外科学]