21-氨基类固醇类药物U-74389G对创伤性脑水肿的影响  

Effect of 21 aminosteroid (U 74389G) on brain edema post traumatic brain injury in rats

作　　者：陈世文[1] 卢亦成[1] 杨中坚[1] 江基尧[1] 于明琨[1] 

机构地区：[1]第二军医大学长征医院神经外科,上海200003

出　　处：《第二军医大学学报》1999年第8期565-567,共3页Academic Journal of Second Military Medical University

摘　　要：目的：探讨２１氨基类固醇类药物 Ｕ７４３８９ Ｇ 对脑外伤后脑水肿和离子含量的影响。方法：分别采用干／湿质量法测定伤后脑含水量，原子吸收光谱分析法测定脑组织内离子含量。结果：伤侧脑组织含水量外伤组较对照组显著增加，但治疗组含水量比外伤组又显著降低。 Ｎａ＋ 、 Ｃａ２＋ 含量外伤组较对照组明显增加，但治疗组比外伤组显著降低； Ｋ＋ 、 Ｍｇ２＋ 含量外伤组较对照组明显降低，但治疗组较外伤组有不同程度的升高。结论： Ｕ７４３８９ Ｇ 能有效地减轻脑外伤后脑水肿。Objective: To explore the effect of 21 aminosteroid (U 74389G) on brain edema post traumatic brain injury (TBI) in rats. Methods: Water content of brain after TBI was assayed by means of dry/wet weight methodology, and the content of ion was measured by an atom absorption spectrum analysis apparatus. Results: The turbulence of sodium, potassium, calcium and magnesium after TBI could be alleviated by U 74389G. The increased water content of injured brain tissue could also be alleviated by the administration of U 74389G. Conclusion: The study indicates that U 74389G could effectively improve brain edema after TBI.

关 键 词：21-氨基类固醇 脑水肿 颅脑损伤 U-74389G 

分 类 号：R651.150.6[医药卫生—外科学] R742.705[医药卫生—临床医学]