老年高血压病患者血浆血管活性肽水平的临床研究  

CLINICAL STUDY OF PLASMA PEPTIDES IN ELDERLY HYPERTENSIVE PATIENTS

作　　者：曾志羽[1] 李醒三[1] 陶新智[1] 黄瑞衡[2] 易忠[2] 

机构地区：[1]广西医科大学第一附属医院心血管病研究所,南宁530021 [2]广西医科大学第一附属医院,南宁530021

出　　处：《广西医科大学学报》1999年第4期420-421,共2页Journal of Guangxi Medical University

基　　金：广西区科技厅自然科学基金!资助项目(桂科青 973 10 0 4)

摘　　要：目的 :探讨老年高血压病患者血浆中降钙素基因相关肽 ( c GRP)、心钠素 ( ANP)、内皮素 ( ET)的浓度变化与不同程度血压水平的关系。方法 :采用放射免疫分析方法 ,分别检测 88例老年高血压病患者和 3 0例正常老年人的 c GRP、 ANP、ET的浓度 ,高血压病患者再按舒张压分为 3组。结果 :血浆 c GRP水平随高血压病程度的增加而下降 ,与平均动脉压( MAP)呈负相关 ( r =- 0 .62 4 3 ,P <0 .0 5 ) ,血浆 ANP、ET水平随血压水平升高而升高 ,与 MAP呈较好的相关关系 (r =0 .6871,P <0 .0 1;r =0 .65 16,P <0 .0 1)。结论 :血浆血管活性肽水平是影响高血压病的发生。Objective:To study the relations between elderly essential hypertension (EH) and calcitonin gene related peptide(cGRP),atrial natriuretic peptide(ANP) and endothelin(ET).Methods:Immunor radiometric essay was used to measure the plasma peptides levels in 88 EH patient,classifing them into three groups according to diastolic blood pressure with 30 elderly healthy controls Results:The levels of plasma cGRP was lower than those of controls,and the cGRP was negatively correlated with mean artery pressure (MAP) (r=-0 624 3,P<0 05),but the levels of plasma ANP,ET were higher than those of controls,and the ANP,ET were positively correlated with MAP (r=0 687 1,P<0 01;r=0 651 6,P<0 01) Conclusion:The levels of plasma peptides were the important factors in developing of elderly essential hypertension

关 键 词：高血压 老年人 血管活性肽 CGRP ANP ET 

分 类 号：R544.102[医药卫生—心血管疾病]