创面生物活性玻璃修复材料促进家猪创面愈合的实验研究  

Promotion of Wound Healing by Bioactive Glass Material in Susscrota Domestica

作　　者：王增辉[1] 黄海[1] 革军[1] 常江 王臻[1] 

机构地区：[1]第四军医大学附属骨科医院骨五科全军骨科重点实验室,陕西西安710015 [2]中科院硅酸盐上海研究所生物材料与组织工程研究中心,上海200050

出　　处：《现代生物医学进展》2011年第9期1617-1620,共4页Progress in Modern Biomedicine

摘　　要：目的:观察创面生物活性玻璃修复材料对家猪皮肤创面的促愈合作用。方法:选择14头家猪,随机分成7组,每组2头,在每头猪的脊柱两旁制造3个4×4cm的全层皮肤缺损的创面模型,每头猪6个创面又分成实验组和空白对照组,于试验后每天观察创面愈合情况,第1、3、7、14、21、28、35天图像分析计算创面愈合率,并同时取创面组织行组织学染色,观察各组材料对家猪皮肤全层缺损创面愈合的影响。结果:在涂材料的实验组和空白对照组创面愈合时间分别是23.19±1.27d、29.52±1.54d两组组间比较,具有统计学意义(P<0.05);实验组的创面愈合率在各时间段均高于空白对照组,差异有统计学意义(P<0.05);组织学观察实验组的上皮化程度、表皮生长、成纤维细胞、毛细血管数量均好于空白对照组。结论:创面生物活性玻璃修复材料对家猪皮肤创面愈合具有促进作用,可作为一种新型的促愈合覆盖材料进一步研究。Objective： To observe the facilitative function of wound healing through bioactive glass material in Susscrota domestica. Method： Fourteen pig models of skin wounds with loss of their full-thickness layers （ each pig with 6 wounds of 3cm×3cm） were estab- lished for the observation of the effects on the wound healing. The biological active glass materials were fully sprinkled into the impinge- ments. Results： The healing time of experimental and blank group were 23.19±1.27d and 29.52±1.54d, respectively （P0.05）. The heal- ing rate was significantly higher and the healing time was significantly shorter in the experimental group than in the control group （P 0.05）. The histological examination demonstrated that the epithelialization condition was also much better in the experimental group. Conclusion： The bioactive glass material may be considered as a prospective method in promoting the healing of wound with a loss of full-thickness skin.

关 键 词：生物活性玻璃 创面愈合 家猪 

分 类 号：Q953[生物学—动物学] R641[医药卫生—外科学]