负载金属离子的5A沸石的体外抗菌实验  

Study on Antibacterial Ability of the New Type of Hemostat for Combat Injury in Vivo

作　　者：吕小星[1] 陈绍宗[1] 李学拥[1] 赵聪颖[1] 赵雨千[1] 雷战军[1] 

机构地区：[1]第四军医大学唐都医院整形烧伤外科,陕西西安710038

出　　处：《现代生物医学进展》2011年第9期1688-1690,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨负载金属离子的5A沸石的体外抗菌作用。方法:选用金黄色葡萄球菌、铜绿假单孢菌、白色念珠菌,利用倍比稀释法对5A沸石组、磺胺嘧啶银组及载不同浓度Ag+、Zn2+5A沸石共15组进行了体外抗菌试验研究,确定最佳抗菌效果离子负载方案。结果:三种细菌的MIC,双金属离子负载在抗菌上具有协同载Ag+5A沸石分别达到了125μg/ml^500μg/ml、31.25μg/ml^500μg/ml、250μg/ml^500μg/ml;附载Zn2+5A沸石分别达到了12.5mg/ml^25mg/ml、6.25mg/ml^50mg/ml、25mg/ml;负载双离子5A沸石分别为250μg/ml^500μg/ml、62.5μg/ml^500μg/ml、500μg/ml。结论:5A沸石负载金属离子后均具有抗菌作用,且抗菌作用与附载金属离子的量正相关;负载相同质量Ag+的5A沸石较附载Zn2+者具有更强的抗菌作用;双金属离子负载在抗菌上具有协同作用;2%Ag++8%Zn2+与2%Ag++10%Zn2+及4%载银组与阳性对照组无显著性差异。Objective： To explore the 5A zeolite load metal ions in vitro antibacterial action. Methods： Select staphylococcus au- reus, the pseudomonas aeruginosa, candida albicans, use times than dilution method to study the vitro antibacterial experiment on 5A ze- olite group, sulfonamides silver group, and altogether 15 groups which bases loaded with different concentrations Ag＋, Zn2＋, 5A zeolite. In the end we determine the optimal antibacterial effect ion load scheme. Results： These three kinds of bacteria in the MIC, loaded with Ag ＋, 5A zeolite respectively reached 125mg/ml ~ 500mg/ml, 31.25 mg/ml ~ 500mg/ml, 250mg/ml ~ 500mg/ml and loaded with Zn2＋ 5A zeo- lite respectively reached 12.5 mg/ml ~ 25mg/ml, 6.25 mg/ml ~ 50mg/ml, 25mg/ml, loaded with double ion 5A zeolite respectively reached 250mg/ml ~500mg/ml, 62.5mg/ml^500mg/ml, 500mg/ml. Conclusion： 5A zeolite loaded with metal ions all have the antibacte- rial effect, and the amount that the antibacterial action is positive correlation with the metal ions＇amount.Loaded with the same quality of 5A zeolite Ag＋ has a stronger antibacterial action than those loaded with Zn2＋. Dual metal ions loaded material has a collaborative ef- fect in antibacterial property. Meanwhile, 2% Ag＋ ＋8%Zn2＋,2% Ag＋ ＋10%Zn2＋ with 4% silver group have no significant differences from the positive control group.

关 键 词：5A沸石 止血剂 抗菌 MIC 

分 类 号：R282.76[医药卫生—中药学] R285.5[医药卫生—中医学]