干扰素γ和白介素10在慢性乙型重型肝炎中的变化  

INF-γ and IL-10 in patients with chronic serious hepatitis B

作　　者：郭晓东[1] 熊璐[1] 李小溪[1] 刘树红[1] 李筱涵[1] 孙志强[1] 史晨辉[1] 赵景民[1] 

机构地区：[1]解放军第302医院,北京100039

出　　处：《现代生物医学进展》2011年第9期1697-1699,共3页Progress in Modern Biomedicine

基　　金：国家传染病重大专项基金(2008ZX10002-005-6)

摘　　要：目的:探讨INF-γ和IL-10在慢性乙型重型肝炎中的作用。方法:搜集不同患者血样,提取血清,使用ELISA方法检测不同患者不同时期的血清INF-γ和IL-10水平,并进行相关统计。结果:本研究发现,和其它肝炎对照组及健康对照组相比,慢性乙型重型肝炎患者的血清INF-γ水平显著升高,IL-10水平显著降低。尽管在不同预后的患者中,INF-γ水平差异并不明显,但是随着治疗生效,INF-γ水平会出现明显的下降。结论:慢性乙型重型肝炎和其它慢性肝炎相比,INF-γ和IL-10表达存在着差异,而且INF-γ可能是一种比较有效的监控慢性重型肝炎病程以及疗效的指标。Objective： To investigate the role of INF-γ and IL-10 in chronic serious hepatitis B patients. Methods： Sera of differ- ent groups of patients were collected and IL-10 and INF-γ serum levels were detected by ELISA. Result： Statistic analysis showed that compared with normal control or other hepatitis B patients, the chronic serious hepatitis B patients showed significantly higher serum INF-γ level and lower serum IL-10 level. The INF-γ level had no difference between the patient who was cured or not. But when pa- tients were cured, the INF-γ level was decreased significantly while IL-10 did not changed a lot. Conclusion： Compared with other type of hepatitis B patients, INF-γ and IL-10 level balance in chronic serious hepatitis B patients was disturbed, and INF-γ may become a potential molecular marker to monitor the disease process.

关 键 词：慢性乙型重型肝炎 干扰素Γ 白介素10 

分 类 号：R512.62[医药卫生—内科学]