侧脑室内注射神经肽对大鼠胃粘膜血流量的影响  

Effects of Neuropeptides Given Intracerebroventriculary on Gastric Mucosal Blood Flow in Rats

作　　者：许宏俐[1] 顾洛[1] 程光[1] 田苏平[1] 李栋生[1] 

机构地区：[1]南京医科大学生理学教研室,南京210029

出　　处：《南京医科大学学报（自然科学版）》1999年第5期393-395,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的　研究某些神经肽在中枢对大鼠胃粘膜血流量 (GMBF)的影响。方法　采用氢气清除法测定大鼠GMBF,分别向侧脑室内微量注射降钙素基因相关肽 (CGRP)、促胃液素 - 17(G1 7)、甲硫脑啡肽 (Met- enk)、铃蟾肽 (Bom )、神经肽 Y(NPY)和生长抑素 (SS)时 GMBF的变化。结果　 1CGRP、G1 7均引起 GMBF的显著增加 ,其中 CGRP作用较强 ;NPY则降低 GMBF;而 Met- enk、Bom、SS对 GMBF无显著影响。 2一氧化氮 (NO)生物合成阻滞剂 L-硝基精氨酸甲基酯 (L- NAME)可完全阻断 CGRP引起的 GMBF增加效应 ,而对 G1 7所引起的效应仅部分阻断。结论　中枢 CGRP、G1 7、NPY对 GMBF有显著的调节作用 ,其中 CGRP、G1 7对 GMBF的增加效应与Objective Effects of some central neuropeptides on GMBF were studied. Methods Hydrogen gas clearance technique was used to measure GMBF. CGRP, G 17 , Bom, Met enk, NPY and SS were injected into cerebroventricle, respectively. Results ①CGRP and G 17 significantly increased GMBF; the effect of CGRP was more potent than that of G 17 ; NPY decreased GMBF, but Bom, Met enk, SS had no effects on it. ②The gastric mucosal hyperemic response induced by CGRP was inhibited completely by L NAME, whereas that induced by G 17 was inhibited partially. Conclusion These results indicated that some central neuropeptides played important roles in controlling GMBF, and that the hyperemic responses caused by CGRP and G 17 were in some way related to NO.

关 键 词：胃粘膜血流量 神经肽 一氧化氮 

分 类 号：R333.2[医药卫生—人体生理学] Q516[医药卫生—基础医学]