SHIV-1157i及衍生病毒的研究进展  

Progress in Research on SHIV-1157i and Its Variations

作　　者：金光[1] 丛喆[1] 王卫[1] 魏强[1] 

机构地区：[1]中国医学科学院,北京协和医学院,医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021

出　　处：《中国比较医学杂志》2011年第5期66-69,共4页Chinese Journal of Comparative Medicine

基　　金：“十一五”国家科技重大专项课题(2009ZX10004-402,2009ZX10004-307)

摘　　要：C亚型是世界上流行的HIV-1主要亚型,带有HIV-1 C亚型env区的SHIV和相应的非人灵长类模型是研究人类艾滋病的有效工具。SHIV-1157i及其衍生病毒能够成功地通过黏膜途径感染恒河猴和猪尾猴,并诱发艾滋病类似症状,而且恒河猴缓慢的发病进程与人类感染HIV-1相似。因此,掌握SHIV-1157i及其衍生病毒感染恒河猴的发病规律并探索其机制,将对研究人类HIV-1感染和发病机制,以及评价HIV-1 C亚型env区为靶点的艾滋病候选疫苗具有重要意义。Human immunodeficiency virus type 1（HIV-1） clade C is the most prevalent clade in the world,and simian-human immunodeficiency virus（SHIV） encoding HIV-1 clade C env and by which the nonhuman primates model is made are efficient tools for investigation of human acquired immune deficiency syndrome（AIDS）.SHIV-1157i and variations from SHIV-1157i can successfully infect rhesus macaques and pig-tailed macaques via mucosa and causing symptoms like AIDS eventually,and the slow process of onset in the in vivo model of rhesus macaques resulted from these SHIVs is similar to HIV-1 infection from human being.Therefore,to elucidate the pathogenesis of infection of rhesus macaques by SHIV-1157i and its variations is of great significance for investigating HIV infection and pathogenesis in human being,and for development of candidate AIDS vaccines targeting HIV-1 clade C env.

关 键 词：SHIV-1157i SHIV-1157ipd3N4 恒河猴 猪尾猴 

分 类 号：R332[医药卫生—人体生理学]