逍遥散对愤怒模型小鼠脑组织中IL-1β、TNF-α的影响  

Effect of Xiaoyaosan on IL-1β,TNF-α in brain tissue of anger model mouse

作　　者：赵焕瑛[1] 喻凯[1] 李子清[1] 周宁[1] 富晓楠[1] 曾维娜[1] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031

出　　处：《中药药理与临床》2011年第2期9-10,共2页Pharmacology and Clinics of Chinese Materia Medica

基　　金：中央高校基本科研业务费专项资金专题研究项目(SWJTU09ZT28)资助

摘　　要：目的:探讨逍遥散对愤怒小鼠脑组织中白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平影响。方法:用50只小鼠分为正常组,模型组,逍遥散高剂量组(11g/kg)、中剂量组(7g/kg)、低剂量组(3g/kg)。夹尾刺激7天后测定其智力水平,小鼠断头处死取脑组织,匀浆取上清液,用酶联免疫吸附实验(ELISA)检测IL-1β,TNF-α水平变化。结果:模型组动物记忆力下降,IL-1β、TNF-α升高,使用逍遥散治疗后IL-1β、TNF-α降低。结论:逍遥散能够有效改善愤怒引起的食欲下降、学习能力降低等。同时逍遥散能够降低愤怒应激引起的脑组织中IL-1β和TNF-α的异常升高,趋于正常。Objective：To explore the effect of Xiaoyaosan on IL-1β and TNF-α in brain tissue of anger mouse.Methods： Fifty mice were randomly allocated to five groups（normal control group,model group,low dose group,middle dose group,and high dose group）.The mice were enraged with nipping their tails except normal control group.Low dose group,middle dose group and high dose group were treated with Xiaoyaosan.IL-1β and TNF-α in brain tissue of the mice were quantitated with ELISA.Results： Content of IL-1β and TNF-α decrease after treatment.Conclusion：Xiaoyaosan can reduce content of IL-1β and TNF-α in brain tissue of anger mouse,improve learning and memory capacity.

关 键 词：逍遥散 白介素-1Β 肿瘤坏死因子-Α 应激 愤怒 

分 类 号：R285[医药卫生—中药学]