麝香与冰片及其配伍对脑缺血缺氧小鼠模型的影响  

The influence of musk,borneol and the compatibility of them on the mice of cerebral ischemia and anoxia

作　　者：王洋[1] 王建[1] 班炳坤[1] 田竞[1] 岳欣[1] 曾南[1] 夏厚林[1] 

机构地区：[1]成都中医药大学,成都611137

出　　处：《中药药理与临床》2011年第2期96-98,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973计划)批准号:2007CB512606

摘　　要：目的:考察麝香与冰片及其各配比对脑缺血缺氧小鼠模型的影响。方法:采用亚硝酸钠中毒性缺氧、小鼠断头、尾静脉注射氯化镁、尾静脉注射空气等所致脑缺血缺氧模型,观察药物对脑缺血缺氧小鼠的存活时间的影响。结果:①单味麝香、冰片均能显著延长亚硝酸钠中毒性缺氧、断头、尾静脉注射空气小鼠的存活时间,冰片还能延长尾静脉注射氯化镁小鼠存活时间;②麝香与冰片配伍能显著延长亚硝酸钠中毒性缺氧、断头、尾静脉注射空气以及氯化镁所致缺氧缺血模型小鼠的存活时间。③与各单味药比较,麝香与冰片配伍无显著增效作用。结论:单味麝香、冰片以及二者配伍,对小鼠脑缺血缺氧均有显著的保护作用,提示二者配伍有"存效"作用,但未能呈现显著的"相须相使"增效作用。Objective ：To investigate the effect of musk,borneol and compatibility of them on cerebral ischemia and anoxia in mice.Methods ：The mouse models of cerebral anoxia and ischemia were established by sodium nitrite,guillotining and intravenous injection of magnesium chloride or air,to observe the influence of the survival time of the mouse models after drugs.Results： ①Musk and borneol could remarkably lengthen the survival time of the mouse models which were established by sodium nitrite,guillotining and air injection（P0.05,P0.01）;Moreover,borneol could lengthen the survival time of the mice model injected magnesium chloride（P0.01）.②Compatibility of musk and borneol could lengthen the survival time of the mouse models established by sodium nitrite,guillotining and intravenous injection of magnesium chloride or air（P0.05,P0.01）.③Compared with musk and borneol,the compatibility could not remarkably improve efficiency（P0.05）.Conclusion： Musk,borneol and the compatibility of them have protective effect obviously on cerebral ischemia and anoxia in mice,suggesting that the compatibility could keep the efficacy,whereas there is no greater efficiency of mutual reinforcement and mutual assistance on the compatibility than the single.

关 键 词：麝香 冰片 配伍 脑缺血 脑缺氧 

分 类 号：R285[医药卫生—中药学]