绝经后骨质疏松治疗方法的近期疗效观察与比较  

Effects of Different Therapies on Post-menopause Osteoporosis

作　　者：连帆[1] 王于[2] 杨岫岩[1] 詹钟平[1] 叶玉津[1] 陈冬莹[1] 邱茜[1] 李昊[1] 

机构地区：[1]中山大学附属第一医院风湿内科,广东广州510080 [2]中山大学介入放射科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2011年第3期379-382,共4页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：【目的】回顾性观察并比较绝经后骨质疏松几种常用治疗方法的疗效。【方法】282例绝经后骨质疏松患者分为3组:A组,给予骨化三醇胶丸0.25μg和钙尔奇D3600mg,均每日1次;B组,在骨化三醇和钙尔奇D3的基础上给予鲑鱼降钙素50U隔日1次至疼痛缓解,改为每周1次;C组,在骨化三醇和钙尔奇D3的基础上给予伊班膦酸钠3mg静脉滴注,每3个月1次。随访时间1年。分别在基线和12个月后记录骨密度,SF-36量表评价的生活质量和VAS疼痛评分。【结果】A组患者在骨密度、生活质量和疼痛评分均略有好转,但与基线比较未达显著性差异;B组患者在骨密度、生活质量和疼痛评分均有较大改善,与基线比有显著性差异;C组患者在上述指标均有明显改善,与基线比有显著性差异,且临床用药方法简单,依从性强。【结论】治疗绝经后骨质疏松,需联合用药,单纯补充钙剂和活性维生素D3不能有效提高骨密度;鲑鱼降钙素止痛迅速,能在一定程度改善骨密度和生活质量;伊班膦酸钠能提高骨密度、改善生活质量,且依从性好。[Objective]To explore the efficacy of different therapies on post-menopause osteoporosis retrospectively.[Methods]A total of 282 cases of post-menopause patients with osteoporosis were enrolled and 3 different therapies were found：A） caltrate ＋ Vit D3;B） caltrate ＋ Vit D3 ＋ calcitonin;C） caltrate ＋ Vit D3 ＋ ibandronate.All patients were followed up for 1 year.BMD,quality of life based on SF-36,and VAS at baseline and 12th month were documented.[Results] Patients in group A improved in all the indexes above,though no significance was found in the assessment.Patients in group B improved significantly in BMD,quality of life and VAS when compared to baseline.Patients in group C improved significantly in all the indexes,and had better patient compliance.[Conclusion] Post-menopause osteoporosis should be treated with combined therapy.Calcitonin would provide rapid pain relieve.Ibandronate had better efficacy in BMD improvement,quality of life and VAS than calcitonin.

关 键 词：绝经后骨质疏松 骨密度 伊班膦酸 鲑鱼降钙素 生活质量 

分 类 号：R59[医药卫生—内科学]