柴胡舒肝汤对脂肪肝模型动物的影响  

Effect of Chaihu Shugan decoction on fatty liver model in chicken

作　　者：张雨[1] 韦倩[2] 

机构地区：[1]吉林大学和平校区门诊部,吉林长春130062 [2]长春中医药大学附属医院,吉林长春130021

出　　处：《中国兽医学报》2011年第6期870-874,共5页Chinese Journal of Veterinary Science

基　　金：国家"十一五"科技支撑资助项目(2008BADB4B04-4)

摘　　要：采用高脂日粮饲喂海兰褐蛋公雏,制作脂肪肝动物模型,再以柴胡舒肝汤进行干预。结果显示,试验组鸡只逐渐出现类似脂肪肝综合征的临床症状,实验室检验血清呈黄色稠膏凝脂状,血脂含量显著升高,剖检肝脏肿大呈土黄色泽,肝脏脂肪含量明显升高,表明以高脂日粮加丙基硫氧嘧啶人工造模成功。中药预防组在其饮水中加入4.5mL柴胡舒肝汤,结果较好地对抗了高脂日粮与丙基硫氧嘧啶的作用,试验鸡没有出现相应临床症状与实验室检验指标,表明柴胡舒肝汤对高脂日粮加丙基硫氧嘧啶所致脂肪肝有预防作用。对已发生脂肪肝病变的鸡以柴胡舒肝汤进行治疗,使相关临床症状逐步消失,肝脏病变与其他检验指标得到恢复,表明柴胡舒肝汤对高脂日粮加丙基硫氧嘧啶所致脂肪肝有治疗作用,可将在其饮水中加入4.5mL柴胡舒肝汤作为推荐剂量。试验中没有发现动物对柴胡舒肝汤呈现不良反应。To observe the effectiveness and safety of Chaihu Shugan decoction on the prevention and therapy for chicken fatty liver syndrome.The fatty liver models were established in male chicks of Hy-line brown fed with high-fat feeds and treated with Chaihu Shugan decoction.The fatty liver models were established successfully in chicken fed with high-fat feeds plus propylthiouracil.The clinical symptoms were similar to fatty liver syndrome.The blood fat markedly increased in the yellow serum with the appearance of congealed fat.The fat content increased remarkably in the yellowish-brown and swollen livers.In the preventive group treated with 4.5 mL of Chaihu Shugan decoction,no relevant clinical symptom and examination indexes showed,indicating that this formula has preventive effect on the fatty liver induced by high-fat feeds plus propylthiouracil.In the therapeutic group treated with Chaihu Shugan decoction,the corresponding clinical symptom disappeared as well as pathological changes of liver and examination indexes were better reinstated,indicating that this formula has therapeutic effect on the fatty liver induced by high-fat feeds plus propylthiouracil.The recommended dosage of this formula is 4.5 mL in the drinking water.In addition,no side effects of this formula appeared in the chicken.

关 键 词：中药 柴胡舒肝汤 脂肪肝 动物模型 

分 类 号：S853.7[农业科学—临床兽医学]