甘西鼠尾草中三个新的萜类化合物  

Three New Terpenoids from Salvia przewalskii Maxim

作　　者：杨阳[1] 吴志军[1] 杨颖博[1] 来威[1] 孙连娜[2] 陈万生[1] 

机构地区：[1]解放军第二军医大学附属长征医院药学部,上海200003 [2]解放军第二军医大学药学院,上海200433

出　　处：《高等学校化学学报》2011年第6期1318-1322,共5页Chemical Journal of Chinese Universities

基　　金：上海科学技术委员会科技专项资金项目(批准号:02DZ19107)资助

摘　　要：采用反复硅胶、葡聚糖凝胶、反相硅胶及MC I凝胶柱色谱等多种色谱方法分离纯化了甘西鼠尾草的化学成分,根据理化性质和波谱数据对化合物的结构进行了鉴定.由甘西鼠尾草的根和根茎的50%乙醇提取物中得到了2个新的二萜化合物,命名为甘西鼠尾三醇A(1)和甘西鼠尾三醇B(2),同时得到了一个新的单萜苷化合物,命名为甘西鼠尾甲苷(3).Salvia przewalskii Maxim.（Labiatae） is widely distributed in the western areas of China,such as Gansu,Sichuan,Yunnan and Tibet provinces.And it has been used as a substitute in Chinese folk medicine for S.miltiorrhiza Bge.（Dan Shen）.The mainly chemical constituents of S.przewalskii are diterpenoids and phenolic acids.In this work,isolation and purification were carried out repeatedly by silica gel,Sephadex LH-20,ODS C_18 and MCI gel column chromatography.Two new diterpenoids,named ganxintriol A（1） and ganxintriol B（2）,and a new monoterpenoid glycoside,named ganxinoside A（3）,were obtained from 50% ethanol extract of the roots and rhizomes of S.przewalskii.Their structures were established on the basis of physical methods,chemical methods and spectral data.

关 键 词：甘西鼠尾草 化学成分 甘西鼠尾三醇A 甘西鼠尾三醇B 甘西鼠尾甲苷 

分 类 号：O629.13[理学—有机化学] O629.61[理学—化学]