左氧氟沙星注射剂致不良反应120例分析  

Analysis of Adverse Drug Reactions of 120 Cases Induced by Levofloxacin

作　　者：杨怀勇[1] 邓永平[2] 

机构地区：[1]云南省肿瘤医院药剂科,昆明市650118 [2]四川平昌县人民医院药剂科,平昌县636400

出　　处：《中国药房》2011年第24期2256-2257,共2页China Pharmacy

摘　　要：目的:了解左氧氟沙星注射剂致不良反应(ADR)的一般规律及特点,为合理用药提供参考。方法:采用回顾性分析方法对云南地区使用左氧氟沙星注射剂致ADR的住院患者进行随访。结果:2000例使用左氧氟沙星患者中发生ADR120例,发生率为6.0%;男性、女性各占66.7%、33.3%;临床表现主要为消化系统症状(如腹泻、恶心和呕吐),其次为皮肤过敏反应,还有部分表现为神经系统症状(如头晕和失眠);118例经积极治疗后痊愈,有2例好转;严重ADR4例,给予积极治疗后均痊愈。ADR的发生与老龄、用药不合理、合并用药和既往有左氧氟沙星过敏史有关(P<0.05)。结论:不合理用药是导致左氧氟沙星ADR发生的主要原因。OBJECTIVE：To study the occurrence of adverse drug reaction （ADR） induced by levofloxacin and rational use of drugs. METHODS： All inpatients treated with levofloxacin in our hospital were observed prospectively. The occurrence of adverse drug reaction was analyzed. RESULTS： Of 2 000 patients, there were 120 cases of adverse drug reactions, accounting for 6.0%. Male and female accounted for 66.7% and 33.3%, retrospectively. Clinical manifestations were gastrointestinal symptoms （such as diarrhea, nausea and vomiting）, followed by skin allergies, part of the performance of the nervous system symptorms （such as dizziness and insomnia）; 118 cases recovered after active treatment, 2 cases improved, 4 patients with severe ADR received active treatment then were cured. Adverse drug reactions were associated with aging, unreasonable medication, drug combination and previous allergy history related to levofloxacin （P0.05）.CONCLUSIONS： The irrational use of levofloxacin is recognized as one of the main reasons causing the occurrence of ADR.

关 键 词：左氧氟沙星 不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学]