头孢美唑致不良反应18例文献分析  

Literature Analysis of 18 Cases of Adverse Drug Reactions Caused by Cefmetazole

作　　者：龙敏[1] 王颖[2] 龙秀英[1] 

机构地区：[1]成都市第六人民医院,成都市610051 [2]四川省食品药品检验所,成都市610097

出　　处：《中国药房》2011年第24期2262-2263,共2页China Pharmacy

摘　　要：目的:探讨头孢美唑致不良反应(ADR)发生的特点及规律,促进临床合理用药。方法:收集1990年1月-2010年10月国内医药期刊有关头孢美唑致ADR个案报道,共18例,并进行分析、评价。结果:头孢美唑致ADR主要表现为皮肤黏膜症状(38.11%)、循环系统症状(22.22%)和过敏反应(20.63%);50岁以上的老年人(50.00%)发生率最高,66.67%的ADR发生在用药24h内。结论:临床应重视头孢美唑引起的ADR,用药时应加强对患者的观察,以减少严重ADR发生。OBJECTIVE： To explore the characteristics and regularity of ADRs induced by cefmetazole. METHODS： A total of 18 reports about ADRs caused by cefmetazole collected from domestic medical journals during Jan. 1990 to Oct. 2010 were analyzed and evaluated. RESULTS： Adverse drug reactions caused by cefmetazole mainly manifested as skin mucous membrane symptoms （38.11%）, symptoms of the circulatory system （22.22%） and allergic reactions （20.63%）; the elderly aged 50 or above （50.00%） had the highest rate, and 66.67% adverse drug reaction occurred within 24 h after administration. CONCLUSION： Clinical attention should be paid cefmetazole-induced adverse drug reactions and medical observation should be strengthened during medication to reduce the serious adverse drug reaction.

关 键 词：头孢美唑 药品不良反应 分析 

分 类 号：R969.3[医药卫生—药理学]