卡维地洛治疗慢性心力衰竭疗效的系统评价  

Systematic Review of Therapeutic Efficacy of Carvedilol in the Treatment of Chronic Heart Failure

作　　者：梁丽梅[1] 廖广仁[1] 何腾辉[2] 

机构地区：[1]广东省人民医院药学部/广东省医学科学院,广州市510080 [2]广东药学院,广州市510220

出　　处：《中国药房》2011年第24期2276-2278,共3页China Pharmacy

摘　　要：目的:对卡维地洛治疗慢性心力衰竭相关文献进行系统评价,为临床用药提供参考。方法:查阅中文已公开发表的有关卡维地洛治疗慢性心力衰竭的临床随机对照试验文献,以左心室射血分数(LVEF)和心率为评价指标,采用Cochrane协作网的软件RevMan4.2进行Meta分析。结果:有5项研究纳入Meta分析,总样本数为459。LVEF有效率差值为7.67,95%可信区间(5.54,9.79),位于无效线右侧,具有统计学意义。心率有效率差值为-9.96,95%可信区间(-13.97,-5.96),位于无效线左侧,具有统计学意义。结论:卡维地洛治疗慢性心力衰竭对LVEF和心率均有改善作用。OBJECTIVE： To evaluate relevant literatures about carvedilol in the treatment of chronic heart failure systematically, and to provide reference for clinical drug use. METHODS： Published literatures of randomized controlled trials about carvedilolin in the treatment of chronic heart failure were reviewed. Using LVEF and heart rate as evaluation index, Meta-analysis was conducted using RevMan 4.2 software on the Cochrane pensonnel network. RESULTS： There were five studies included in Meta-analysis, and the total number of sample was 459. Left ventricular ejection fraction efficient difference was 7.67 [95% confidence interval （5.54, 9.79）] located on the right side of inefective line, which had statistical significance. Heart rate efficient difference was -9.96 [95% confidence interval （-13.97,-5.96）] located on the left side of ineffective line, which had statistical significance. CONCLUSION： Carvedilol for chronic heart failure can improve left ventricular ejection fraction and heart rate.

关 键 词：卡维地洛 慢性心力衰竭 META分析 

分 类 号：R972.3[医药卫生—药品]