2,6-二甲基吡喃酮的合成  

Synthesis of 2,6-Dimethyl-γ-pyrone

作　　者：喻爱和[1] 曾红艳[2] 段正康[2] 马帅[2] 贺玉平[2] 

机构地区：[1]湖南机电职业技术学院生物化工系,湖南长沙410151 [2]湘潭大学化工学院,湖南湘潭411105

出　　处：《精细化工》2011年第6期612-615,共4页Fine Chemicals

摘　　要：以乙酰丙酮和乙酸甲酯为原料,四氢呋喃为溶剂,乙醇钠为催化剂,进行克莱森缩合反应合成2,6-二甲基吡喃酮。通过单因素实验考察了影响2,6-二甲基吡喃酮合成的各项因素。结果表明,当n(乙酰丙酮)∶n(乙酸甲酯)∶n(乙醇钠)=1.0∶2.5∶2.0、反应温度为85℃、反应时间为6 h时,以乙酰丙酮计的2,6-二甲基吡喃酮收率可达13.32%,经HPLC测定其色谱纯度为95.37%。2,6-Dimethyl-γ-pyrone was synthesized via the Claisen condensation with acetylacetone and methyl acetate as raw materials,tetrahydrofuran as solvent,sodium ethylate as catalyst.The effect of reaction conditions on the properties of 2,6-dimethyl-γ-pyrone was investigated by method of single factor experiments.The results show that the yield of 2,6-dimethyl-γ-pyrone could reach 13.32% and its content was 95.37% calculated by acetylacetone under the following reaction conditions： the molar ratio of acetylacetone to methyl acetate and sodium ethylate was 1.0∶ 2.5∶ 2.0,the reaction temperature was 85 ℃,and the reaction time was 6 hours.

关 键 词：2 6-二甲基吡喃酮 乙酰丙酮 克莱森缩合反应 精细化工中间体 

分 类 号：TQ253.1[化学工程—有机化工]