卵巢癌血液供应模式及预后相关性分析  

Clinical prognosis significance of microcirculation patterns in ovarian carcinoma

作　　者：王俊艳[1] 赵秀兰[2] 赵楠[2] 张丹芳[2] 张诗武[2] 孙保存[2,3] 

机构地区：[1]天津医科大学组织学与胚胎学教研室 [2]天津医科大学病理学教研室 [3]天津医科大学肿瘤研究所

出　　处：《中国实用妇科与产科杂志》2011年第6期464-466,共3页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：天津市应用基础及前沿技术研究项目(项目编号:10JCYBJC12900)

摘　　要：目的探讨卵巢癌的血液供应模式和卵巢癌中血管生成拟态(vasculogenicmimicry,VM)存在的临床病理意义。方法收集天津医科大学附属肿瘤医院1991年1月至1999年12月临床和预后资料完整的卵巢癌组织标本84例,复习切片明确诊断后进行CD31和PAS双重染色,探讨卵巢癌的血液供应模式,并分析与其相关的临床病理意义。结果在卵巢癌组织中存在内皮依赖性血管、马赛克血管和血管生成拟态3种血液供应模式。84例卵巢癌组织中36例(42.86%)组织中观察到VM。VM组患者出现转移的比例为94.4%(34/36),高于无VM组的47.9%(23/48),两者差异有统计学意义(P=0.000)。利用Kaplan-Meier生存曲线比较卵巢癌患者VM组与无VM组的生存率,结果表明VM组患者生存率(69.4%,25/36)明显低于无VM患者(83.3%,40/48)(P=0.044)。结论卵巢癌中存在内皮依赖性血管、马赛克血管和VM3种血液供应模式,VM是卵巢癌患者预后的不利因素,有VM的患者易发生转移,预后比无VM的患者差。Objective To observe the microcirculation patterns in ovarian carcinoma and the clinical pathological significance of vasculogenic mimicry. Methods The clinical and pathological data of eighty-four cases of ovarian carcinoma were collected in the study. The microcirculation patterns were observed in ovarian carcinoma by immunohistochemical and histochemieal double staining of CD31 and PAS. The clinical significance of vasculogenic mimicry was assessed. Re- suits The endothelial dependent vessel, mosaic vascular and vasculogenic mimicry were observed in ovarian carcinoma. Vasculogenic mimicry channels were found i36 of the 84 ovarian carcinoma cases （42.86%）. There was a statistical significance in metastasis between the cases with and without vasculogenic mimicry （ P = 0. 000 ）. Kaplan-Meier survival analysis was peformed in this study, the results indicated that the survival rate for patients with VM （ 69.4% , 25/36 ） was significantly worse than that of patients without vaseulogeic mimicry（ 83.3% ,40/48 ） （ P = 0. 044 ）. Conclusion The endothelial dependent vessel, mosaic vascular and vasculogenic mimicry exists in ovarian carcinoma. Vasculogenie mimicry is an unfavorable factor influencing prognosis of the patients with ovarian carcinoma. The patients with vaseulogenie mimicry channels in the tumor are prone to suffer the metastasis. Prognosis for patients with vasculogenic mimicry channels in ovarian carcinoma is poorer than that in patients without vasculogenie mimicry.

关 键 词：卵巢癌 血管生成拟态 肿瘤转移 预后 免疫组织化学 

分 类 号：R71[医药卫生—妇产科学]