鲨鱼软骨粉合剂治疗血吸虫病患者前后肝脾病变的超声影像观察  

Observation on Ultrasonographic Images of Liver and Spleen in Patients with S.japonica before and after Oral Administration of SCP Combining Reagent

作　　者：陈家旭[1] 李允鹤[1] 骆伟[1] 龚唯[1] 夏超明[1] 胡永德[1] 甘黎明 舒辉 汤立志 成游兰 熊海波 

机构地区：[1]苏州医学院寄生虫学教研室,苏州215007 [2]湖南省临湘市血吸虫防治医院

出　　处：《苏州医学院学报》1999年第9期948-950,共3页Acta Academiae Medicinae Suzhou

摘　　要：　１８ 例日本血吸虫病患者 Ｂ 超检查为肝实质回声增强，光点增粗、增强，分布不均匀的光点型血吸虫病肝图像。经 Ｓ Ｃ Ｐ 合剂治疗肝实质病变得到不同程度的恢复与改善。大剂量（ Ｓ Ｃ Ｐ 合剂，１１００ｍｇ／ｄ） 组治疗１ 、２ 个月的有效率分别为６２ ．５ ％ 和８７ ．５ ％ ；小剂量（ Ｓ Ｃ Ｐ合剂，７００ｍｇ／ｄ） 组治疗后１ 、２ 个月的有效率分别为４４ ．４ ％ 和８８ ．９ ％ 。两组同一时期的有效率无显著性差异，且均能有效地减轻肝实质病变，并使肝门静脉内径缩小，脾肿大减轻。表明 Ｓ Ｃ Ｐ合剂可使虫卵肉芽肿病变减弱，肝纤维化改善，病人临床体征也有所好转。Eighteen patients with schistosomiasis japonica determined by COPT and IHA test were randomly divided into two groups,and their livers and spleens were examined by ultrasonography/before and after oral administration of SCP combining reagent at a dosage of 1100mg/d(group Ⅰ) or 700mg/d(group Ⅱ) for 14 days,Before treatment the liver parenchyma lesion was observed,and the images of the liver were light dot type,and after treatment the lesion was improved in variable degrees.In group I the effective rate was 62.5% one month after treatment and 87.5% two months after treatment.In group Ⅱ the effective rates one and two months after treatment were 44.4% and 88.9% respectively.The effective rate was not significantly different at the same stage after treatment between the two groups,and two dosages of treatment both could reduce the liver parenchyma lesion effectively,and decrease the inner diameter of portal vein,and diminish splenomegaly.The results obtained from clinical trial suggest that SCP combining reagent could lead to diminution of the size of hepatic granuloma,and improve hepatic fibrosis and clinical syndrome of patients with schistosomiasis.

关 键 词：日本血吸虫病 鲨鱼软骨粉合剂 超声波诊断 

分 类 号：R532.21[医药卫生—内科学]