SPECT肾功能检查对伊拉地平肾保护作用的评价  

Evaluation on Effects of Isradipine on Renal Protection by SPECT

作　　者：徐峰坡[1] 董慎安[1] 张玮[1] 吴星红[1] 卢国元[2] 

机构地区：[1]苏州医学院附属一院核医学科,苏州215006 [2]苏州医学院附属一院心内科,苏州215006

出　　处：《苏州医学院学报》1999年第9期994-995,共2页Acta Academiae Medicinae Suzhou

摘　　要：４０ 例轻、中度高血压病患者服安慰剂１ 周后，予伊拉地平２ ．５ｍｇ Ｂｉｄ ×４ Ｗ 口服。应用核素肾 Ｓ Ｐ Ｅ Ｃ Ｔ功能检查，结果表明：肾有效血浆流量、肾小球滤过率显著增加（ Ｐ＜ ０ ．０１） ，肾血管阻力显著降低（ Ｐ＜０ ．０１） ，而肾滤过分数不受影响。结论：伊拉地平对高血压病患者肾功能有具有保护作用，有益于高血压病的长期治疗。The protective effects of isradipine on renal function were evaluated in a study on 40 patients with mild-moderate essential hypertension.Isradipine was administered at adosage of 2.5mg twice daily for 4 weeks after receiving placbo for one week.SPECT were used for detecting renal function.The results of these evaluation indicated that there was significantly increasing in ERPF and GFR (P<0.01) and significant decreasing in resistance of renal vessel (P<0.01),and FF remained unchanged.It suggests that isradipine has a protective efffect on renal function and it is beneficial for the long-term therapy.

关 键 词：高血压病 伊拉地平 肾功能 SPECT 

分 类 号：R544.1[医药卫生—心血管疾病] R692.04[医药卫生—内科学]