痰瘀同治法治疗2型糖尿病痰瘀证患者血浆TNF-α、CRP的临床观察  

Clinical observation on treating plasma TNF-α,CRP in T2DM patients with syndrome of phlegm-blood stasis with Tanyu Tongzhi therapy

作　　者：黄雯晖[1] 杨柳青[2] 衡先培[2] 

机构地区：[1]福建省宁德市医院,福建宁德352100 [2]福建中医药大学附属人民医院,福建福州350000

出　　处：《中医临床研究》2011年第9期1-3,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察以痰瘀同治立法的芎蒌通脉方干预治疗2型糖尿病痰瘀证,对患者血浆相关炎症因子肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)的影响。方法:入选150例2型糖尿病痰瘀证患者,随机分成治疗组98例,对照组52例。所有患者均接受有关的糖尿病健康教育,并以予常规降糖治疗及饮食控制,治疗组加服芎蒌通脉方煎剂,每日一剂,分两次服,疗程为14天。观察治疗前和治疗后患者血浆TNF-α、CRP水平、空腹血浆血糖。结论:以痰瘀同治立法的芎蒌通脉方干预治疗2型糖尿病痰瘀证,能明显降低患者血浆相关炎症因子TNF-α水平,同时有助于降低CRP水平,改善血管慢性炎症,显著改善患者的临床症状,从而抑制糖尿病血管损伤。Objective： To explore the effect of TCM Xionglou Tongmai decoction which was founded on the basis of Tanyu Tongzhi therapy on serum levels of tumor necrosis factor-a （TNF-a） and C-reactive protein （CRP） in T2DM patients with syndrome of plegm-blood stasis- Methods： 150 T2DM patients with syndrome of plegm-blood stasis were selected and randomly divided into the treatment group （n=98） and the control group （n=52）- Patients attended to the education courses for diabetes and were treated with hypoglycemic agent in routine and reasonable diet- To those patients in treatment group, Xionglou Tongmai decoction was given addition -nally with one dose taken twice per day, 14 days for a course of treatment- Assayed serum levels of TNF-a, CRP, fasting blood glucose （FBG） before and after treatment- Conclusions： Xionglou Tongmai decoction which was founded on the basis of Tanyu Tongzhi therapy could obviously decreased serum levels of inflammatory cytokines TNF-α and conduce to decreased the levels of CRP, ameliorate vascular chronic inflammation, and alleviate clinical symptoms of patients, then could resist diabetic vascular injuries-

关 键 词：2型糖尿病 肿瘤坏死因子Α C反应蛋白 血糖 痰瘀同治 芎蒌通脉方 

分 类 号：R587-1[医药卫生—内分泌]