国产氟苯水杨酸胶囊剂与进口片剂溶出度的比较  

Study on the dissolution of diflunisal capsules

作　　者：林芳[1] 王胜浩[1] 王国强[1] 韩锦文[1] 

机构地区：[1]浙江省医学科学院药物所,杭州310013

出　　处：《药学实践杂志》1999年第6期339-341,共3页Journal of Pharmaceutical Practice

摘　　要：目的：对国产氟苯水杨酸胶囊剂与进口片剂进行溶出度的比较。方法：参照ＵＳＰ２３ 版氟苯水杨酸片剂的溶出度测定方法，用紫外分光光度仪测定其含量。结果：测定方法的平均回收率为１００－２７％ ，ＲＳＤ为０－６２％ ，溶出度的重现性与均一性都较好。胶囊剂与片剂溶出８０％ 所需的时间分别为１２－８０ｍｉｎ 与１３－０４ｍｉｎ。结论：胶囊剂与片剂均符合质量标准中所规定的溶出限度，Ｔ８０ 两者无显著性差异。OBJECTIVE:The vitro release of diflunisal capsules were compared with the tablets (imported,made by Merck Corporation).METHODS:Referring to the USP ⅩⅩⅢ,the dissolution and the content of two kinds of dosage forms containing diflunisal were determined by UV spectropholometer respectively.RESULTS:The average recovery was 100.27%( RSD =0.62%).The in vitro release of capsules was faster that of diflunisal material and available tablets. T 80 of capsules was 12.8min vs.13.08min of tablets.CONCLUSION:The rate of dissolution has no significance differences between the capsules and the imported tablets.

关 键 词：氟苯水杨酸 胶囊 片剂 溶出度 

分 类 号：R944.5[医药卫生—药剂学] R971.1[医药卫生—药学]