口服甲苯咪唑微丸的药物动力学及生物利用度  

The pharmacokinetics and relative bioavailability of mebendazole pellets after oral administration

作　　者：李岩[1] 孙殿甲[1] 苗爱东 王本富 

机构地区：[1]新疆医学院药学系,乌鲁木齐830054 [2]空军乌鲁木齐医院

出　　处：《中国医院药学杂志》1999年第11期649-651,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：比较５ 只家兔单剂量口服甲苯咪唑微丸及片剂后的药动学与生物利用度。方法：采用ＲＰＨＰＬＣ 法测定血药浓度，３Ｐ８７ 程序计算药动学参数。结果：微丸的Ｃｍａｘ、Ｔ１／２ 、ＡＵＣ分别为６４３．４９ ｎｇ·ｍｌ－ １ 、１ ．０５ ｈ、８ １７０ ．９４ ｈ·ｎｇ·ｍｌ－１ 。结论：微丸与片剂的ＡＵＣ有统计学显著性差异（ Ｐ＜０ ．０５），相对生物利用度为５２８ ．６０ ％ 。OBJECTIVE:Pharmacokinetics and bioavailability of mebendazole pellets and mebendazole tablets were compared in 5 rabbits after single dose oral administration.METHODS:The blood levels of mebendazole were determined by RP HPLC.The 3P87 program was used for the calculation of pharmacokinetic parameters.RESULTS:The C max , T 1/2 and AUC of mebendazole pellets was 643.49 ng·ml -1 , 1.05 h and 8 170.94 h·ng·ml -1 ,respectively.CONCLUSIONS:The statistical analysis for the AUC showed that there was significant difference( P < 0.05 ) between the two products.The relative bioavailability of mebendazole pellets was 528.60% .

关 键 词：甲苯咪唑 微丸 片剂 生物利用度 药物动力学 

分 类 号：R978.63[医药卫生—药品] R944.27[医药卫生—药学]