用血小板功能分析仪和血栓弹力图分析仪监测阿司匹林疗效的临床研究  

Application of PFA-100 and thromboelastograph for monitoring clinical efficacy of aspirin in elderly patients with cardiovascular disease

作　　者：李康[1] 李健[2] 王成彬[2] 王海[2] 杨丽[2] 丛玉隆[2] 

机构地区：[1]解放军第309医院检验科,北京100091 [2]解放军总医院临床检验科,北京100853

出　　处：《中国误诊学杂志》2011年第16期3789-3791,共3页Chinese Journal of Misdiagnostics

摘　　要：目的对比老年心血管患者口服阿司匹林后血小板功能抑制情况,以寻求更方便、可靠的监测心血管疾病的方法。方法每位患者采用血小板聚集仪、血栓弹力图分析仪(TEG)检测血小板聚集率,同时用血小板功能分析仪(PFA-100)检测微孔堵塞时间。结果血小板聚集仪与PFA-100比较测得的抵抗率差异有统计学意义(P<0.005)。而与TEG比较差异无统计学意义(0.10<P<0.25)。结论 PFA-100具有高度的方法学依赖性,在诊断阿司匹林抵抗方面,TEG的诊断效果较PFA-100更为适宜。Objective To compare the situation of inhibited platelet function when the elderly patients with cardiovascular disease who oral aspirin in order to seek more convenient and reliable method to monitor cardiovascular disease.Methods To measure the platelet aggregation rate by PAgT and TEG,and to measure closed time by PFA-100 for each patient.Results The incidence of AR which measured by PAgT and PFA-100 was statistically significant（P0.005）.But there was no statistically significant with TEG（0.10P0.25）.Conclusion PFA-100 is highly dependent,in the diagnosis of aspirin resistance,TEG is more appropriate than PFA-100.

关 键 词：血小板功能试验/仪器和设备 血栓弹力描记术/仪器和设备 阿司匹林/治疗应用 心血管疾病/药物疗法 抗药性 

分 类 号：R446.11[医药卫生—诊断学]