急性冠状动脉综合症患者血浆溶血磷脂酸及基质金属蛋白酶-9水平的检测及意义  

Detection and Significance of Lysophosphatidic Acid and Matrix Metalloproteinase-9 Levels in Patients with Acute Coronary Syndrome

作　　者：刘建华 尚桂莲 董明国 李小好 叶青跃 

机构地区：[1]武汉市科技大学附属天佑医院检验科,湖北武汉430064 [2]武汉市科技大学附属天佑医院急诊科,湖北武汉430064

出　　处：《现代生物医学进展》2011年第10期1956-1958,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨急性冠状动脉综合症(acute coronary syndromes,ACS)患者血浆溶血磷脂酸(1ysophosphatidic acid,LPA)及基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)水平的变化,探讨其在ACS中可能的临床意义。方法:入选100例ACS患者,根据病情将其分为急性心肌梗死(AMI)组50例,不稳定型心绞痛(UAP)组50例,并入选40例健康者作为对照组,分别用无机磷定量法和酶联免疫吸附测定法测定血浆LPA、MMP-9水平。结果:AMI组血浆LPA、MMP-9水平显著高于UAP组(LPA:3.29±0.42vs2.67±0.37;MMP-9:481.7±86.5vs237.85±65.34,P<0.01)并且两组均显著高于对照组(LPA:1.82±0.31;MMP-9:87.42±23.85P<0.01);LPA与MMP-9水平呈正相关(r=0.224,P<0.05)。结论:LPA与MMP-9可能是提示不稳定斑块的形成、破裂,进而导致急性冠状动脉综合征的危险信号。To investigate the level of plasma lysophosphatidic acid（LPA） and matrix metallopmteinase-9（MMP-9） in patients with acute coronary syndromes（ACS） and to explore the potential clinical significance. Method： A total of 100 patients with ACS were divided into two groups：group AMI（AMI） 50 and group unstable angina （UAP） 50,and 40 healthy persons served as control. Plasma LPA and MMP-9 were determined by inorganic phosphours quantitative method and enzyme-linked iaununosorbent assay. Result： LPA and MMP-9 levels were significantly higher in AMI than in UAP （LPA ：3.29±0.42vs2.67±0.37 ;MMP-9：481.7±86.5 vs 237.85±65.34,P〈0. 01）,and in both group were higher than in controll group （LPA：l.82±0.31; MMP-9：87A2±23.85 P〈0.01）; LPA level was positive correlated with MMP-9 （r=0.224, P〈0.05）. Conclusion： LPA and MMP-9 may serve as a potential risk signal to hint the formation and rupture of unstable atherosclerotic plaque of ACS.

关 键 词：急性冠状动脉综合症 溶血磷脂酸 基质金属蛋白酶-9 

分 类 号：R541.4[医药卫生—心血管疾病]