血脂康对低密度脂蛋白体外氧化修饰的影响  

The effect of Xuezhikang on oxidation of low density lipoproteins in virto

作　　者：徐伯平[1] 程蕴琳[1] 鲁翔[1] 

机构地区：[1]南京医科大学第一附属医院,210029

出　　处：《中华内科杂志》1999年第8期520-522,共3页Chinese Journal of Internal Medicine

摘　　要：目的　探讨血脂康对人低密度脂蛋白体外氧化修饰的影响。方法　通过体外实验 ,观察血脂康对铜离子介导人低密度脂蛋白氧化修饰后相对电泳迁移率的变化。结果　低密度脂蛋白在体外铜离子介导下 ,随作用时间延长 ,其相对电泳迁移率增大 ,表明铜离子可诱导低密度脂蛋白发生氧化修饰。当加入血脂康后 ,氧化低密度脂蛋白的相对电泳迁移率各时间点均较对照组低 ,两组相比 ,P <0 .0 5 ,最大抑制率 2 4小时达峰值 ,为 3 3 .5 %。当加入不同浓度血脂康作用 18小时 ,随血脂康浓度增加 ,其氧化低密度脂蛋白的相对电泳迁移率变小 ,抑制加强。结论　铜离子在体外能介导低密度脂蛋白氧化 ,随时间延长 ,氧化程度加重 ;血脂康能抑制铜离子介导的低密度脂蛋白氧化 ,随血脂康浓度增加 ,抑制加强。Objective To study the effect of Xuezhikang on oxidation of human low density lipoprotein. Methods In vitro experiment was used to study the effect of Xuezhikang on the change of human low density lipoprotein. Relative electrophoresis movement rate after oxidation of low density lipopotein mediated by addition of copper ion was observed. Results Oxidation of low density lipoprotein mediated by copper ion was accelerated as the time of action prolonged and the process was accompanied by increased relative electrophoresis movement rate. Oxidation of low density lipoprotein by copper ion was inhibited significantly in the presence of Xue zhikang as comparied with absence of XuezhiKang at all time points. A greater reduction of reative electrophoresis movement rate up to 33.5%, ( P <0.05) was noted. With increase of Xuezhikang concentration, the extent of reduction increased. Conclusion It is shown that human low density lipoprotein can be oxidized by mediation of copeper ion and XuezhiKang may inbibit the extent of oxidation of low density lipoprotion by copper ion.

关 键 词：动脉粥样硬化 脂蛋白类 LDL 血脂康 药理 

分 类 号：R972.6[医药卫生—药品] R543.505[医药卫生—药学]